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Thus, a better understanding of mechanisms of hypertension could lead to novel therapies.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Mineralocorticoid receptors (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) are known to regulate blood pressure by responding to aldosterone in the kidney to regulate sodium retention. Recent evidence supports a direct contribution of the vasculature to control of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and suggests the possibility that <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> antagonists may also lower blood pressure by acting on extrarenal <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This review summarizes existing research considering the role of the vascular <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> in regulating vasoreactivity and blood pressure.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Multiple studies indicate a role for vascular <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> in modulating vasoconstriction and vasorelaxation. Activation of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> in vascular endothelial and smooth muscle cells leads to increased reactive oxygen species production and decreased availability of nitric oxide, important regulators of vascular reactivity.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Transgenic mouse models, including an endothelial <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> overexpressing mouse and a smooth muscle cell\u2010specific <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\u2010knockout mouse, support a direct role for vascular <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> in control of blood pressure.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>This new evidence demonstrating that vascular <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> directly contribute to control of vasoreactivity and blood pressure supports vascular <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> and the pathways they control as novel therapeutic targets to treat hypertension.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12125","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T11:04:42Z","timestamp":1369479882000},"page":"902-909","source":"Crossref","is-referenced-by-count":29,"title":["Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation"],"prefix":"10.1111","volume":"40","author":[{"given":"Kathleen V","family":"Barrett","sequence":"first","affiliation":[{"name":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA USA"},{"name":"Sackler School of Biomedical Graduate Studies Tufts University School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T","family":"McCurley","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Z","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Research Institute Tufts Medical Center Boston MA USA"},{"name":"Sackler School of Biomedical Graduate Studies Tufts University School of Medicine Boston MA USA"},{"name":"Division of Cardiology Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.10.029"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000079505.25750.11"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.189141"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032149"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9424"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00965.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090975"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00728.2009"},{"key":"e_1_2_7_10_1","first-page":"41","article-title":"Identification and role of aldosterone receptors in the cardiovascular system","volume":"61","author":"Lombes M","year":"2000","journal-title":"Ann. 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