{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:30:57Z","timestamp":1768249857657,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":610,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharmacol Physiol"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1111\/1440-1681.12178","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:59:09Z","timestamp":1381539549000},"page":"67-72","source":"Crossref","is-referenced-by-count":4,"title":["Synthetic peptides from heat-shock protein 65 inhibit proinflammatory cytokine secretion by peripheral blood mononuclear cells from rheumatoid arthritis patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Jun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacology; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan-Dan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Jin","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Therapeutic Vaccines Engineering Center; College of Medicine; Xi'an Jiaotong University; Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"10.1111\/1440-1681.12178-BIB0001|cep12178-cit-0001","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00296-010-1446-x","article-title":"Platelet function in rheumatoid arthritis: Arthritic and cardiovascular implications","volume":"31","author":"Gasparyan","year":"2011","journal-title":"Rheumatol. Int."},{"key":"10.1111\/1440-1681.12178-BIB0002|cep12178-cit-0002","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00296-009-1345-1","article-title":"Mean platelet volume in patients with rheumatoid arthritis. The effect of anti-TNF-alpha therapy","volume":"30","author":"Gasparyan","year":"2010","journal-title":"Rheumatol. Int."},{"key":"10.1111\/1440-1681.12178-BIB0003|cep12178-cit-0003","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","article-title":"Neutrophil function in inflammation and inflammatory diseases","volume":"49","author":"Wright","year":"2010","journal-title":"Rheumatology"},{"key":"10.1111\/1440-1681.12178-BIB0004|cep12178-cit-0004","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1172\/JCI37346","article-title":"Many cytokines are very useful therapeutic targets in disease","volume":"118","author":"Feldmann","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1111\/1440-1681.12178-BIB0005|cep12178-cit-0005","first-page":"963","article-title":"The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid arthritis","volume":"29","author":"Hobl","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1111\/1440-1681.12178-BIB0006|cep12178-cit-0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10238-006-0088-5","article-title":"Joint inflammation and cytokine inhibition in rheumatoid arthritis","volume":"6","author":"Christodoulou","year":"2006","journal-title":"Clin. Exp. Med."},{"key":"10.1111\/1440-1681.12178-BIB0007|cep12178-cit-0007","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/art.27631","article-title":"Inhibitors of p38 suppress cytokine production in rheumatoid arthritis synovial membranes: Does variable inhibition of interleukin-6 production limit effectiveness in vivo?","volume":"62","author":"Page","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1111\/1440-1681.12178-BIB0008|cep12178-cit-0008","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/art.24266","article-title":"Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis","volume":"60","author":"Cohen","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1111\/1440-1681.12178-BIB0009|cep12178-cit-0009","doi-asserted-by":"crossref","first-page":"807","DOI":"10.7326\/0003-4819-138-10-200305200-00008","article-title":"Case reports of heart failure after therapy with a tumor necrosis factor antagonist","volume":"138","author":"Kwon","year":"2003","journal-title":"Ann. Intern. Med."},{"key":"10.1111\/1440-1681.12178-BIB0010|cep12178-cit-0010","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.intimp.2008.01.034","article-title":"In-vitro effects of Mycobacterium bovis BCG-lysate and its derived heat shock proteins on cytokines secretion by blood mononuclear cells of rheumatoid arthritis patients in comparison with healthy controls","volume":"8","author":"Sheikhi","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"10.1111\/1440-1681.12178-BIB0011|cep12178-cit-0011","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1002\/eji.1830261116","article-title":"Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein","volume":"26","author":"Haque","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1111\/1440-1681.12178-BIB0012|cep12178-cit-0012","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2249.1996.tb08291.x","article-title":"A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis","volume":"103","author":"Ragno","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1111\/1440-1681.12178-BIB0013|cep12178-cit-0013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2249.1996.929628.x","article-title":"A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis","volume":"103","author":"Kingston","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1111\/1440-1681.12178-BIB0014|cep12178-cit-0014","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1111\/1440-1681.12178-BIB0015|cep12178-cit-0015","unstructured":"Wang M inventor. Xi'an Xinsiwei Patent Mark Agency CO. Ltd assignee Immunomodulatory peptide and its applications for the prevention and \/ or treatment of rheumatoid arthritis. (CN) patent no. 200810150035.8. June 2008"},{"key":"10.1111\/1440-1681.12178-BIB0016|cep12178-cit-0016","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.regpep.2007.04.001","article-title":"Effect of ppMCH derived peptides on PBMC proliferation and cytokine expression","volume":"143","author":"Coumans","year":"2007","journal-title":"Regul. Pept."},{"key":"10.1111\/1440-1681.12178-BIB0017|cep12178-cit-0017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1476-511X-10-75","article-title":"Prostaglandin E(2) binding peptide screened by phage displaying: A new therapeutic strategy in rheumatoid arthritis","volume":"10","author":"Yan","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1111\/1440-1681.12178-BIB0018|cep12178-cit-0018","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/ecam\/nem168","article-title":"Potential use of Plectranthus amboinicus in the treatment of rheumatoid arthritis","volume":"7","author":"Chang","year":"2010","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1111\/1440-1681.12178-BIB0019|cep12178-cit-0019","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1128\/AAC.48.9.3498-3507.2004","article-title":"Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine","volume":"48","author":"Tenney","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1111\/1440-1681.12178-BIB0020|cep12178-cit-0020","first-page":"2","article-title":"Benefit\/risk of therapies for rheumatoid arthritis. Underestimation of the \u2018side effects\u2019 or risks of RA leads to underestimation of the benefit\/risk of therapies","volume":"22","author":"Pincus","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1111\/1440-1681.12178-BIB0021|cep12178-cit-0021","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1517\/13543784.12.7.1087","article-title":"The therapeutic potential of TNF-alpha blockade in rheumatoid arthritis","volume":"12","author":"Paleolog","year":"2003","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1111\/1440-1681.12178-BIB0022|cep12178-cit-0022","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physiolgenomics.00127.2010","article-title":"Gene expression profiling in peripheral blood cells of patients with rheumatoid arthritis in response to anti-TNF-alpha treatments","volume":"43","author":"Meugnier","year":"2011","journal-title":"Physiol. Genomics"},{"issue":"Suppl. 2","key":"10.1111\/1440-1681.12178-BIB0023|cep12178-cit-0023","first-page":"11","article-title":"Pathogenesis of bone and cartilage destruction in rheumatoid arthritis","volume":"42","author":"Goldring","year":"2003","journal-title":"Rheumatology"},{"key":"10.1111\/1440-1681.12178-BIB0024|cep12178-cit-0024","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1359-6101(02)00018-7","article-title":"Cytokines and anti-cytokine biologicals in autoimmunity. Present and future","volume":"13","author":"Andreakos","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1111\/1440-1681.12178-BIB0025|cep12178-cit-0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1196\/annals.1398.020","article-title":"Autoimmune diseases are connected with disturbances in cytokine synthesis, and therapy with IFN-gamma blockers is their main pathogenetic treatment","volume":"1109","author":"Skurkovich","year":"2007","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1111\/1440-1681.12178-BIB0026|cep12178-cit-0026","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3109\/08916934.2012.697592","article-title":"Therapeutic effect of an altered peptide ligand derived from heat-shock protein 60 by suppressing of inflammatory cytokines secretion in two animal models of rheumatoid arthritis","volume":"45","author":"Lorenzo","year":"2012","journal-title":"Autoimmunity"},{"key":"10.1111\/1440-1681.12178-BIB0027|cep12178-cit-0027","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0092-8674(89)90786-1","article-title":"T cell recognition as the target for immune intervention in autoimmune disease","volume":"57","author":"Wraith","year":"1989","journal-title":"Cell"},{"key":"10.1111\/1440-1681.12178-BIB0028|cep12178-cit-0028","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/341482a0","article-title":"Autoimmune disease: Immunotherapy by peptides?","volume":"341","author":"Janeway","year":"1989","journal-title":"Nature"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/1440-1681.12178\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T17:06:04Z","timestamp":1625504764000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,30]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12178","relation":{},"ISSN":["0305-1870"],"issn-type":[{"value":"0305-1870","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12,30]]}}}