{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:33:34Z","timestamp":1787164414264,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T00:00:00Z","timestamp":1395100800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 102-2313-B-018 -001 MY3"],"award-info":[{"award-number":["NSC 102-2313-B-018 -001 MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC 101-2320-B-039-040;"],"award-info":[{"award-number":["NSC 101-2320-B-039-040;"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>\n \n \n \n \n Valproic acid (\n VPA<\/jats:styled-content>\n ) induces haemorrhagic liposis of the cervical muscles in the chicken embryo model (\n CEM<\/jats:styled-content>\n ). Vitamin E and resveratrol (\n RV<\/jats:styled-content>\n ) exhibit prominent anti\u2010oxidative and glutathione (\n GSH<\/jats:styled-content>\n )\u2010protecting effects.\n <\/jats:p>\n <\/jats:list-item>\n \n \n In the present study we hypothesized that vitamin E and\n RV<\/jats:styled-content>\n would ameliorate\n VPA<\/jats:styled-content>\n induced haemorrhagic liposis in chick embryos. To this end, 120 Day 0 fertilized eggs were divided into 10 groups (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 12 in each). The effects of different combinations of\n VPA<\/jats:styled-content>\n (60\u00a0mmol\/L),\n RV<\/jats:styled-content>\n (0.2 and 2.0\u00a0mmol\/L) and vitamin E (0.2 and 2.0\u00a0mmol\/L) applied to Hamburger and Hamilton (\n HH<\/jats:styled-content>\n ) Stage 10 (Day 1.5) embryos were tested in the\n CEM<\/jats:styled-content>\n using established methods.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Both\n RV<\/jats:styled-content>\n and vitamin E (both at 2.0\u00a0mmol\/L) effectively rescued neural tube defects in the early stage\n CEM<\/jats:styled-content>\n and inhibited the malformation rate compared with that in the control group (8.4% and 5.0%\n vs<\/jats:italic>\n 36.5\u00a0\u00b1\u00a03.0%, respectively;\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) and suppressed serum homocysteine and S\u2010adenosylhomocysteine concentrations, downregulated cervical muscular carnitine, triglycerides, H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n , malondialdehyde, interleukin\u20106 and\n \n ACC<\/jats:styled-content>\n <\/jats:italic>\n expression (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05 for all) and upregulated\n \n CPT<\/jats:styled-content>\n 1\n <\/jats:italic>\n expression and\n GSH<\/jats:styled-content>\n (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05 for both).\n <\/jats:p>\n <\/jats:list-item>\n \n \n The haemorrhagic liposis of cervical muscles can be alleviated by\n RV<\/jats:styled-content>\n and vitamin E. It appears that the main mechanism of action of\n RV<\/jats:styled-content>\n and vitamin E in rescuing\n VPA<\/jats:styled-content>\n \u2010induced teratogenicity is through the suppression of reactive oxygen species and upregulation of\n GSH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>","DOI":"10.1111\/1440-1681.12205","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T08:28:45Z","timestamp":1390897725000},"page":"210-219","source":"Crossref","is-referenced-by-count":20,"title":["Resveratrol and vitamin\n E<\/scp>\n rescue valproic acid\u2010induced teratogenicity: The mechanism of action"],"prefix":"10.1111","volume":"41","author":[{"given":"Chiu\u2010Lan","family":"Hsieh","sequence":"first","affiliation":[{"name":"Graduate Institute of Biotechnology Changhua University of Education Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Chou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Taipei Medical University Taichung Hsien Taiwan"},{"name":"Department of Urology Shuang Ho Hospital Taipei Medical University Taichung Hsien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010Xiao","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biotechnology Changhua University of Education Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung\u2010Chi","family":"Peng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taichung Hsien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Y","family":"Peng","sequence":"additional","affiliation":[{"name":"Research Institute of Biotechnology Hungkuang University Taichung Hsien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.10.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(00)00013-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.09.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.072314"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3742"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20082"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp052"},{"key":"e_1_2_7_10_1","first-page":"5616","article-title":"The effect of valproic acid on rat ovarium and the protective role of vitamin E and folic acid: An ultrastructural study","volume":"9","author":"Aktas A","year":"2010","journal-title":"Afr. 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