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Although much is known about different types of neurons and simple reflexes in the intestine, it remains unclear how complex behaviours are generated.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Mathematical modelling is an important tool for assisting the understanding of how the neurons and reflexes can be pieced together to generate intestinal behaviours.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Models have identified a functional role for slow excitatory post\u2010synaptic potentials (<jats:styled-content style=\"fixed-case\">EPSP<\/jats:styled-content>s) by distinguishing between fast and slow <jats:styled-content style=\"fixed-case\">EPSP<\/jats:styled-content>s in the ascending excitation reflex. These models also discovered coordinated firing of similarly located neurons as emergent properties of feed\u2010forward networks of interneurons in the intestine. A model of the recurrent network of intrinsic sensory neurons identified important control mechanisms to prevent uncontrolled firing due to positive feedback and that the interaction between these control mechanisms and slow <jats:styled-content style=\"fixed-case\">EPSP<\/jats:styled-content>s is necessary for the networks to encode ongoing sensory stimuli. This model also showed that such networks may mediate migrating motor complexes.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>A network model of vasoactive intestinal peptide neurons in the submucosal plexus found this relatively sparse recurrent network could produce uncontrolled firing under conditions that appear to be related to cholera toxin\u2010induced hypersecretion.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Abstract modelling of the intestinal fed\u2010state motor patterns has identified how stationary contractions can arise from a polarized network.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>These models have also helped predict and\/or explained pharmacological evidence for two rhythm generators and the requirement of feedback from contractions in the circular muscle.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/1440-1681.12209","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T13:29:20Z","timestamp":1390915760000},"page":"155-164","source":"Crossref","is-referenced-by-count":14,"title":["Mathematical modelling of enteric neural motor patterns"],"prefix":"10.1111","volume":"41","author":[{"given":"Jordan D","family":"Chambers","sequence":"first","affiliation":[{"name":"Department of Physiology University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan A","family":"Thomas","sequence":"additional","affiliation":[{"name":"Florey Neuroscience Institutes Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,18]]},"reference":[{"key":"e_1_2_18_2_1","volume-title":"The Enteric Nervous System","author":"Furness JB","year":"2006"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20010101)262:1<58::AID-AR1011>3.0.CO;2-V"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015907780077141"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(97)00051-8"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90524-X"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.2.G422"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-01-00235.1992"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00067-S"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0547t.x"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.827bv.x"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903140303"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01216705"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90434-H"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00121-2"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.473bb.x"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01189041"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.01052.x"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.177105"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063586"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701967"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90071-B"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-02-00505.1991"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-04-01502.1992"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1899.sp000752"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00551.x"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050001"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013399"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040840"},{"key":"e_1_2_18_30_1","first-page":"303","article-title":"Cholinergic, somatostatin\u2010immunoreactive interneurons in the guinea pig intestine: Morphology, ultrastructure, connections and projections","volume":"187","author":"Portbury AL","year":"1995","journal-title":"J. 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