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In the present study, the antihypertensive effect of and inhibition of vascular remodelling by<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 were investigated in two\u2010kidney, one\u2010clip (2<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) renovascular hypertensive rats. Rats were subjected to the 2<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>procedure and treated with<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 (40 or 80\u00a0mg\/kg per day) for 8\u00a0weeks. Blood pressure was measured in conscious rats. Microalbumin (m<jats:styled-content style=\"fixed-case\">ALB<\/jats:styled-content>) and total protein (<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>) concentrations were determined in the urine, as were plasma concentrations of angiotensin (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ng)<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, calcitonin gene\u2010related peptide (<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>) and angiotensin\u2010converting enzyme 1 (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>). The unclipped kidney was stained with haematoxylin and eosin and Masson trichrome, whereas aortic sections were stained with Masson trichrome. In addition,<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1\u2010induced vasodilatation was evaluated<jats:italic>in vitro<\/jats:italic>in rat mesenteric and renal arteries. Immunohistochemical analysis was used to quantify collagen I and III expression.<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 relaxed rat mesenteric and renal arterial rings<jats:italic>in vitro<\/jats:italic>. Treatment of 2<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hypertensive rats with<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 (40 and 80\u00a0mg\/kg per day) for 8\u00a0weeks significantly decreased blood pressure. In addition,<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 reduced plasma<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ng<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>concentrations and increased plasma<jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>concentrations. At 80\u00a0mg\/kg per day,<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 decreased blood urea nitrogen, m<jats:styled-content style=\"fixed-case\">ALB<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>levels. Histological analysis revealed that<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 reduced renal arteriolar thickness and relieved the structural hypertrophic arteries. Moreover,<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 had an inhibitory effect on vascular remodelling and renal lesions in hypertensive rats. In conclusion, the results suggest that<jats:styled-content style=\"fixed-case\">OW<\/jats:styled-content>1 could potentially be a novel candidate for hypertension intervention.<\/jats:p>","DOI":"10.1111\/1440-1681.12248","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T07:51:33Z","timestamp":1399362693000},"page":"571-578","source":"Crossref","is-referenced-by-count":12,"title":["Antihypertensive and vascular remodelling effects of the imperatorin derivative<scp>OW<\/scp>1 in renovascular hypertension rats"],"prefix":"10.1111","volume":"41","author":[{"given":"Nan","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaizhen","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyu","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Langchong","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.723593"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000242335.32890.c6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2010.12.002"},{"key":"e_1_2_7_5_1","first-page":"897","article-title":"Antiplatelet therapy and anticoagulation in patients with hypertension","volume":"71","author":"Griffin G","year":"2005","journal-title":"Am. 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