{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:43:26Z","timestamp":1762004606004,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian Postgraduate Award"},{"name":"Postgraduate Research Scholarship"},{"name":"National Health and Medical Research Council of Australia (NHMRC)"},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Career Development Fellowship"},{"DOI":"10.13039\/501100001134","name":"Australia-India Strategic Research Fund","doi-asserted-by":"crossref","award":["BF030018"],"award-info":[{"award-number":["BF030018"]}],"id":[{"id":"10.13039\/501100001134","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with atrial fibrillation (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) are at an increased risk of thromboembolism and stroke primarily from the development of thrombi within the left atrium. Pathological changes in blood constituents and atrial endothelial damage promote left atrial thrombus formation. It is not known whether factors predisposing to left atrial thrombus formation in <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> are disease specific or also evident within the normal heart. The present study examined whether there are differences in platelet reactivity, endothelial function and inflammation in blood samples obtained from intracardiac and peripheral sites in subjects within structurally normal hearts. Sixteen patients with diagnosed left\u2010sided supraventricular tachycardia (<jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content>) undergoing a routine elective electrophysiological study and ablation were investigated. Blood samples were taken simultaneously from the femoral vein, right atrium and left atrium, immediately following trans\u2010septal puncture and prior to heparin bolus administration. Between peripheral and atrial sample sites, patients with <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> showed no change in platelet reactivity or aggregation (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010selectin (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>62<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>) <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.91; platelet\u2010derived soluble <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40 ligand <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.9), thrombus formation (thrombin\u2013antithrombin complex; <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.55), endothelial function (von Willebrand factor <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.75; asymmetric dimethylarginine (<jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>) <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.97; nitric oxide <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.61), or inflammation (vascular cell adhesion molecule\u20101 <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.59; intercellular adhesion molecule\u20101 (<jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101) <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.69). However, <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> patients had lower <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101 levels than <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> patients. The present study demonstrates, for the first time, that <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> subjects with structurally normal hearts have consistent haemostatic function between atrial and peripheral sites. These results suggest that the atria of <jats:styled-content style=\"fixed-case\">SVT<\/jats:styled-content> patients do not contain predisposing thrombogenic, endothelial or inflammatory factors that promote and\/or initiate thrombus formation.<\/jats:p>","DOI":"10.1111\/1440-1681.12256","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T18:28:43Z","timestamp":1400092123000},"page":"551-557","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of thrombogenic, endothelial and inflammatory markers in supraventricular tachycardia: a study in patients with structurally normal hearts"],"prefix":"10.1111","volume":"41","author":[{"given":"Carlee D","family":"Schultz","sequence":"first","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetanjali","family":"Rangneker","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han S","family":"Lim","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelique","family":"Fraudeau","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Young","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Roberts\u2010Thomson","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby","family":"John","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Worthley","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanthan","family":"Sanders","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R","family":"Willoughby","sequence":"additional","affiliation":[{"name":"Centre for Heart Rhythm Disorders University of Adelaide and Cardiovascular Investigation Unit Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.11.083"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.042"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00427-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00060-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.10.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103131.70301.4F"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.5.395"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039327.11661.16"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.046"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000044341.43780.C7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2741\/1800"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.6981"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.04.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100310001638814"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.983"},{"key":"e_1_2_8_18_1","first-page":"35","article-title":"Risk factors for and incidence of subtypes of ischemic stroke","volume":"27","author":"Ihle\u2010Hansen H","year":"2012","journal-title":"Funct. Neurol."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000077912.12202.FC"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2000.2531"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00039-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.063"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.47.371"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.3.803"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.225"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.CIR.0000060496.23144.A7","article-title":"Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects","volume":"107","author":"Kielstein JT","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1663"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T22:00:40Z","timestamp":1696370440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/1440-1681.12256"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12256","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"type":"print","value":"0305-1870"},{"type":"electronic","value":"1440-1681"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}