{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:18:31Z","timestamp":1793038711010,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322010, 81170735, 81200582"],"award-info":[{"award-number":["81322010, 81170735, 81200582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2011CB504001, 2012AA02A509, 2011ZX09307-001-02"],"award-info":[{"award-number":["2011CB504001, 2012AA02A509, 2011ZX09307-001-02"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Excellent Young Medical Expert of Shanghai","award":["XYQ2011041"],"award-info":[{"award-number":["XYQ2011041"]}]},{"name":"National Young Top Talent Supporting Program"},{"name":"Shanghai Talent Development Grant","award":["2012041"],"award-info":[{"award-number":["2012041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of the present study was to investigate the effect of the E23K variant of the potassium inwardly rectifying channel, subfamily J, member 11 (<jats:italic><jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>11<\/jats:italic>) gene on gliclazide modified release (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) treatment in newly diagnosed patients with type 2 diabetes mellitus (T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>). A total of 108 diabetic patients with no history of antidiabetic medication was treated with gliclazide <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> for 16\u00a0weeks and underwent follow up at Weeks 2, 4, 8, 12 and 16. All patients were genotyped for <jats:italic><jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>11<\/jats:italic> E23K (rs5219). At baseline, patients with the <jats:styled-content style=\"fixed-case\">KK<\/jats:styled-content> genotype had higher blood glucose and lower serum insulin levels after oral glucose administration than patients with the <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EK<\/jats:styled-content> genotypes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all). During treatment, individuals with the <jats:styled-content style=\"fixed-case\">KK<\/jats:styled-content> genotype had lower fasting glucose levels and were more likely to attain the target fasting glucose level (<jats:italic>P<\/jats:italic><jats:sub>log rank<\/jats:sub>\u00a0=\u00a00.028) than E allele carriers. Patients with the <jats:styled-content style=\"fixed-case\">KK<\/jats:styled-content> genotype had larger augmentations in changes (\u0394) in acute insulin response (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.049) and \u0394 body mass index (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.003). Moreover, patients with the <jats:styled-content style=\"fixed-case\">EK<\/jats:styled-content> genotype had a lower variance in changes in fasting insulin levels (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.049) and homeostasis model assessment of \u03b2\u2010cell function (P\u00a0=\u00a00.021) than those with the <jats:styled-content style=\"fixed-case\">KK<\/jats:styled-content> genotype. The findings of the present study suggest that the <jats:italic><jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>11<\/jats:italic> E23K variant is associated with a greater effect of sulphonylurea treatment in newly diagnosed Chinese patients with T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12280","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T12:37:15Z","timestamp":1407847035000},"page":"748-754","source":"Crossref","is-referenced-by-count":23,"title":["<i><scp>KCNJ<\/scp>11<\/i> E23K variant is associated with the therapeutic effect of sulphonylureas in <scp>C<\/scp>hinese type 2 diabetic patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai 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Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai 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