{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:43:41Z","timestamp":1769053421774,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The chemokine, fractalkine, independently enhances the vulnerability of coronary atherosclerotic plaques. The present study investigated the combined effects of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>36 and fractalkine on coronary plaque progression in patients with unstable angina pectoris. In the present study, 120 unstable angina pectoris patients undergoing coronary angiography and intravascular ultrasound were divided into two groups: an intermediate lesion group (lumen diameter stenosis 50\u201370%, 80 patients) and a severe lesion group (at least one lesion with lumen diameter stenosis &gt;\u00a070%, 40 patients). The control group consisted of 40 healthy age\u2010 and sex\u2010matched subjects. Concentrations of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>36 and fractalkine were measured by enzyme\u2010linked immunosorbent assay. Major adverse cardiovascular events were monitored over a 2\u2010year follow up. Intravascular ultrasound showed that patients with severe lesions had more calcified and mixed plaques, and a larger plaque area and plaque burden than patients with intermediate lesions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05\u20130.01). More patients with severe lesions underwent stent deployment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) than those with intermediate lesions. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>36 and fractalkine concentrations were significantly higher in the severe lesion patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and both had significant positive correlations (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with the plaque burden of atherosclerotic lesions. Using the matched nested case\u2013control study, we found that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>36 and fractalkine levels were higher in patients with recurrent major adverse cardiovascular events than controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In conclusion, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>36 and fractalkine both promote, and might synergistically enhance, the progression of coronary atherosclerotic plaques.<\/jats:p>","DOI":"10.1111\/1440-1681.12302","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T16:41:43Z","timestamp":1410799303000},"page":"863-869","source":"Crossref","is-referenced-by-count":7,"title":["Circulating <scp>CD<\/scp>36 and fractalkine levels are associated with vulnerable plaque progression in patients with unstable angina pectoris"],"prefix":"10.1111","volume":"41","author":[{"given":"Rui Jian","family":"Li","sequence":"first","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"},{"name":"Department of Emergency Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Fu","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xue","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"},{"name":"Department of Emergency Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Guo","family":"Chen","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"},{"name":"Department of Emergency Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179705"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp138"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802481237"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03416.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01147.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000190672.36490.7b"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-1457"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04836.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50272-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9259"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm093"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187930"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.03.036"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp081"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152511794182855"}],"container-title":["Clinical 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