{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:02:30Z","timestamp":1786708950414,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":274,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81102428"],"award-info":[{"award-number":["81102428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81070197"],"award-info":[{"award-number":["81070197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Jiangsu Province","award":["BK20141240"],"award-info":[{"award-number":["BK20141240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharmacol Physiol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1111\/1440-1681.12308","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T16:41:48Z","timestamp":1410799308000},"page":"976-985","source":"Crossref","is-referenced-by-count":17,"title":["Rescue of cardiac failing and remodelling by inhibition of protein phosphatase\u00a01<i>\u03b3<\/i>is associated with suppression of the alternative splicing factor-mediated splicing of Ca<sup>2+<\/sup>\/calmodulin-dependent protein kinase\u00a0<i>\u03b4<\/i>"],"prefix":"10.1111","volume":"41","author":[{"given":"Ru-Jia","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Juan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Zhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; School of Medicine; Nantong University; Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"10.1111\/1440-1681.12308-BIB0001|cep12308-cit-0001","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.2741\/3472","article-title":"Role of PP1 in the regulation of Ca2+ cycling in cardiac physiology and pathophysiology","volume":"14","author":"Nicolaou","year":"2009","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1111\/1440-1681.12308-BIB0002|cep12308-cit-0002","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1161\/CIRCRESAHA.110.237644","article-title":"Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling","volume":"108","author":"Qian","year":"2011","journal-title":"Circ. Res."},{"key":"10.1111\/1440-1681.12308-BIB0003|cep12308-cit-0003","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1128\/MCB.22.12.4124-4135.2002","article-title":"Type 1 phosphatase, a negative regulator of cardiac function","volume":"22","author":"Carr","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1111\/1440-1681.12308-BIB0004|cep12308-cit-0004","doi-asserted-by":"crossref","first-page":"H1539","DOI":"10.1152\/ajpheart.00515.2008","article-title":"Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality","volume":"295","author":"Bruchert","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1111\/1440-1681.12308-BIB0005|cep12308-cit-0005","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/cvr\/cvn208","article-title":"Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy","volume":"80","author":"El-Armouche","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1111\/1440-1681.12308-BIB0006|cep12308-cit-0006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(88)80378-8","article-title":"Two isoforms of protein phosphatase 1 may be produced from the same gene","volume":"232","author":"Cohen","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1111\/1440-1681.12308-BIB0007|cep12308-cit-0007","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1432-1033.1990.tb19464.x","article-title":"Drosophila contains three genes that encode distinct isoforms of protein phosphatase 1","volume":"194","author":"Dombradi","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1111\/1440-1681.12308-BIB0008|cep12308-cit-0008","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/j.1349-7006.1990.tb02690.x","article-title":"Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas","volume":"81","author":"Sasaki","year":"1990","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1111\/1440-1681.12308-BIB0009|cep12308-cit-0009","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/elps.201000615","article-title":"Serine\/threonine-protein phosphatase 1 alpha levels are paralleling olfactory memory formation in the cd1 mouse","volume":"32","author":"Winding","year":"2011","journal-title":"Electrophoresis"},{"key":"10.1111\/1440-1681.12308-BIB0010|cep12308-cit-0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/cvr\/cvq252","article-title":"Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling","volume":"89","author":"Aoyama","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1111\/1440-1681.12308-BIB0011|cep12308-cit-0011","doi-asserted-by":"crossref","first-page":"14286","DOI":"10.1074\/jbc.M801377200","article-title":"Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a parkinson disease model","volume":"283","author":"Brown","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1111\/1440-1681.12308-BIB0012|cep12308-cit-0012","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1083\/jcb.200508154","article-title":"Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability","volume":"172","author":"Trinkle-Mulcahy","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1111\/1440-1681.12308-BIB0013|cep12308-cit-0013","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1745-7262.2007.00307.x","article-title":"Protein phosphatase PP1 gamma 2 in sperm morphogenesis and epididymal initiation of sperm motility","volume":"9","author":"Chakrabarti","year":"2007","journal-title":"Asian. J. Androl."},{"key":"10.1111\/1440-1681.12308-BIB0014|cep12308-cit-0014","first-page":"111","article-title":"Regulation of sperm function by protein phosphatase PP1gamma2","volume":"63","author":"Vijayaraghavan","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"10.1111\/1440-1681.12308-BIB0015|cep12308-cit-0015","first-page":"375","article-title":"Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells","volume":"86","author":"Sogawa","year":"1994","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1111\/1440-1681.12308-BIB0016|cep12308-cit-0016","first-page":"125","article-title":"Enhanced expression of catalytic subunit isoform PP1 gamma 1 of protein phosphatase type 1 in malignant fibrous histiocytoma","volume":"86","author":"Yamada","year":"1994","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1111\/1440-1681.12308-BIB0017|cep12308-cit-0017","doi-asserted-by":"crossref","first-page":"C167","DOI":"10.1152\/ajpcell.00145.2013","article-title":"PP1\u03b3 functionally augments the alternative splicing of CaMKII\u03b4 through interaction with ASF","volume":"306","author":"Huang","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1111\/1440-1681.12308-BIB0018|cep12308-cit-0018","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0167-4889(94)90221-6","article-title":"Identification and characterization of delta B-CaM kinase and delta C-CaM kinase from rat heart, two new multifunctional Ca2+\/calmodulin-dependent protein kinase isoforms","volume":"1221","author":"Edman","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1111\/1440-1681.12308-BIB0019|cep12308-cit-0019","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1023\/A:1010899724222","article-title":"Expression of Ca2+\/calmodulin-dependent protein kinase II delta-subunit isoforms in rats with hypertensive cardiac hypertrophy","volume":"220","author":"Hagemann","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"10.1111\/1440-1681.12308-BIB0020|cep12308-cit-0020","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1083\/jcb.126.4.839","article-title":"Alternative splicing introduces a nuclear localization signal that targets multifunctional cam kinase to the nucleus","volume":"126","author":"Srinivasan","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1111\/1440-1681.12308-BIB0021|cep12308-cit-0021","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M108525200","article-title":"The cardiac-specific nuclear deltaB isoform of Ca2+\/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2a activity","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1111\/1440-1681.12308-BIB0022|cep12308-cit-0022","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltac isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ. Res."},{"key":"10.1111\/1440-1681.12308-BIB0023|cep12308-cit-0023","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2004.11.036","article-title":"ASF\/SF2-regulated CaMKII\u03b4 alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle","volume":"120","author":"Xu","year":"2005","journal-title":"Cell"},{"key":"10.1111\/1440-1681.12308-BIB0024|cep12308-cit-0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbrc.2011.04.128","article-title":"The deltaa isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the hdac4-mef2 signaling pathway","volume":"409","author":"Li","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1111\/1440-1681.12308-BIB0025|cep12308-cit-0025","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/hmg\/ddm284","article-title":"Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing","volume":"17","author":"Novoyatleva","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1111\/1440-1681.12308-BIB0026|cep12308-cit-0026","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jmb.2010.08.024","article-title":"Mechanism of dephosphorylation of the SR protein ASF\/SF2 by protein phosphatase 1","volume":"403","author":"Ma","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1111\/1440-1681.12308-BIB0027|cep12308-cit-0027","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1093\/nar\/gkr1289","article-title":"C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1","volume":"40","author":"Sumanasekera","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1111\/1440-1681.12308-BIB0028|cep12308-cit-0028","doi-asserted-by":"crossref","first-page":"e67582","DOI":"10.1371\/journal.pone.0067582","article-title":"2-Phenylethynesulfonamide prevents induction of pro-inflammatory factors and attenuates LPS-induced liver injury by targeting NHE1-Hsp70 complex in mice","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/1440-1681.12308-BIB0029|cep12308-cit-0029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1742-2094-10-129","article-title":"2,3,4\u2032,5-tetrahydroxystilbene 2-O-\u03b2-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-\u03baB in microglia","volume":"10","author":"Huang","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1111\/1440-1681.12308-BIB0030|cep12308-cit-0030","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1073\/pnas.0813013106","article-title":"The delta isoform of CaMKII is required for pathological cardiac hypertrophy and remodeling after pressure overload","volume":"106","author":"Backs","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1111\/1440-1681.12308-BIB0031|cep12308-cit-0031","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/01.RES.0000069685.20258.F1","article-title":"Transgenic CaMKIIdeltaC overexpression uniquely alters cardiomyocyte Ca2+ handling: Reduced SR Ca2+ load and activated SR Ca2+ release","volume":"92","author":"Maier","year":"2003","journal-title":"Circ. Res."},{"key":"10.1111\/1440-1681.12308-BIB0032|cep12308-cit-0032","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1590\/S0100-879X2005000900002","article-title":"CaMKIIdelta overexpression in hypertrophy and heart failure: Cellular consequences for excitation-contraction coupling","volume":"38","author":"Maier","year":"2005","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1111\/1440-1681.12308-BIB0033|cep12308-cit-0033","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1038\/sj.onc.1204829","article-title":"Protein phosphatase 1alpha-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein","volume":"20","author":"Wang","year":"2001","journal-title":"Oncogene"},{"key":"10.1111\/1440-1681.12308-BIB0034|cep12308-cit-0034","doi-asserted-by":"crossref","first-page":"e35875","DOI":"10.1371\/journal.pone.0035875","article-title":"Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling","volume":"7","author":"Miyazaki","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1111\/1440-1681.12308-BIB0035|cep12308-cit-0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1042\/BC20090091","article-title":"TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis","volume":"102","author":"Wang","year":"2010","journal-title":"Biol. Cell"},{"key":"10.1111\/1440-1681.12308-BIB0036|cep12308-cit-0036","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molcel.2007.08.010","article-title":"S6k1-mediated disassembly of mitochondrial URI\/PP1\u03b3 complexes activates a negative feedback program that counters S6k1 survival signaling","volume":"28","author":"Djouder","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1111\/1440-1681.12308-BIB0037|cep12308-cit-0037","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/CIRCRESAHA.109.210914","article-title":"Cardioprotection by CaMKII\u03b4B is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70","volume":"106","author":"Peng","year":"2010","journal-title":"Circ. Res."},{"key":"10.1111\/1440-1681.12308-BIB0038|cep12308-cit-0038","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1074\/jbc.M611507200","article-title":"Activation of CaMKII\u03b4C is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis","volume":"282","author":"Zhu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1111\/1440-1681.12308-BIB0039|cep12308-cit-0039","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.RES.0000189270.72915.D1","article-title":"Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes","volume":"97","author":"Chen","year":"2005","journal-title":"Circ. Res."},{"key":"10.1111\/1440-1681.12308-BIB0040|cep12308-cit-0040","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI200316326","article-title":"Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+\/calmodulin kinase II","volume":"111","author":"Zhu","year":"2003","journal-title":"J. Clin. Invest."}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/1440-1681.12308\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T14:10:20Z","timestamp":1717337420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12308","relation":{},"ISSN":["0305-1870"],"issn-type":[{"value":"0305-1870","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}