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The present study investigated the long\u2010term anti\u2010inflammatory property of resveratrol in the retinas of type 2 diabetic rats. Male Wistar rats were divided into four groups: normal control, diabetic control, resveratrol\u2010treated normal rats and resveratrol\u2010treated diabetic rats. Type 2 diabetes was induced by a single dose injection of streptozotocin (50\u00a0mg\/kg; i.p.) 15\u00a0min after the administration of nicotinamide (110\u00a0mg\/kg; i.p.) in 12\u2010h fasted rats (the streptozotocin\u2013nicotinamide type 2 diabetic model). Oral resveratrol administration (5\u00a0mg\/kg per day for 4\u00a0months) significantly improved glucose tolerance, and alleviated hyperglycemia and weight loss in diabetic rats. Furthermore, resveratrol administration significantly decreased the elevated levels of nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B activity, and m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression, tumour necrosis factor alpha level and apoptotic cells in the retinas of the diabetic rats. Furthermore, resveratrol did not significantly affect plasma insulin levels. Long\u2010term resveratrol administration has beneficial anti\u2010inflammatory properties in a rat model of diabetes. However, whether resveratrol exerts its effects directly or through reducing blood glucose levels requires further investigation.<\/jats:p>","DOI":"10.1111\/1440-1681.12326","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T11:36:21Z","timestamp":1415187381000},"page":"63-68","source":"Crossref","is-referenced-by-count":36,"title":["Anti\u2010inflammatory properties of resveratrol in the retinas of type 2 diabetic rats"],"prefix":"10.1111","volume":"42","author":[{"given":"Farhad","family":"Ghadiri Soufi","sequence":"first","affiliation":[{"name":"Molecular Medicine Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Arbabi\u2010Aval","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozhgan","family":"Rezaei Kanavi","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Ahmadieh","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"8 18 671","DOI":"10.1155\/2013\/818671","article-title":"Inflammation, haemostatic disturbance, and obesity: Possible link to pathogenesis of\u00a0diabetic retinopathy\u00a0in type 2 diabetes","volume":"2013","author":"Tomi\u0107 M","year":"2013","journal-title":"Mediators Inflamm."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22138"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.4.363"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.044"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2005"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820539909069542"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00155-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1476fje"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(99)00117-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/295784"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1795"},{"key":"e_1_2_6_13_1","first-page":"1418","article-title":"TNF\u2010\u03b1 mediated apoptosis plays an important role in the development of early diabetic retinopathy and long\u2010term histopathological alterations","volume":"15","author":"Joussen AM","year":"2009","journal-title":"Mol. 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