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In the present study, we compared the effects of cilnidipine and amlodipine (an L\u2010type CCB) on cardiac and renal functions in spontaneously\u2010hypertensive rats injected with adriamycin (ADR). After the weekly administration of ADR for 3\u00a0weeks, spontaneously\u2010hypertensive rats were orally administered cilnidipine (20\u00a0mg\/kg per day), amlodipine (3\u00a0mg\/kg per day), or vehicle once daily for 4\u00a0weeks. A control group received saline rather than ADR, followed by vehicle for 4\u00a0weeks. Cilnidipine and amlodipine produced similar reductions in blood pressure after 4\u00a0weeks. Cilnidipine ameliorated ADR\u2010induced heart and kidney damage, whereas amlodipine slightly improved cardiac echocardiographic parameters, but did not protect against ADR\u2010induced renal damage. Cilnidipine (but not amlodipine) suppressed the reflex SNS and RAAS hyperactivity caused by their antihypertensive effects. Furthermore, cilnidipine and amlodipine treatment decreased the urinary levels of adrenocortical hormones. The protective effects of cilnidipine against ADR\u2010induced renal and cardiac dysfunction might be associated with its blockade of N\u2010type calcium channels, in addition to its pleiotropic actions, which include the inhibition of the RAAS.<\/jats:p>","DOI":"10.1111\/1440-1681.12360","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T06:44:51Z","timestamp":1421131491000},"page":"344-352","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of the cardioprotective and renoprotective effects of the L\/N\u2010type calcium channel blocker, cilnidipine, in adriamycin\u2010treated spontaneously\u2010hypertensive rats"],"prefix":"10.1111","volume":"42","author":[{"given":"Shizuka","family":"Aritomi","sequence":"first","affiliation":[{"name":"Research Institute Ajinomoto Pharmaceuticals Kanagawa Japan"},{"name":"Department of Pharmacology and Therapeutics Toho University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Harada","sequence":"additional","affiliation":[{"name":"Research Institute Ajinomoto Pharmaceuticals Kanagawa Japan"},{"name":"Department of Pharmacology and Therapeutics Toho University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Sugino","sequence":"additional","affiliation":[{"name":"Research Institute Ajinomoto Pharmaceuticals Kanagawa Japan"},{"name":"Department of Pharmacology and Therapeutics Toho University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Research Institute Ajinomoto Pharmaceuticals Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarou","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Research Institute Ajinomoto Pharmaceuticals Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics Toho University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2009.00079.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01521-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-007-0984-y"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210396"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00407.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.89"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200202000-00023"},{"key":"e_1_2_5_9_1","first-page":"117","article-title":"Comparative effect of clinidipine and quinapril on left ventricular mass in mild essential hypertension","volume":"29","author":"Sakata K","year":"2003","journal-title":"Drugs Exp. 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