{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:21:14Z","timestamp":1777692074229,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immature endothelial progenitor cells (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>) carrying osteocalcin (<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>) might mediate vascUlar calcification in coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). Spotty calcification within atherosclerotic plaque is associated with cardiovascular events. The aim of the present study was to assess the correlation between immature <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> levels and spotty calcification in <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients. In the 224 <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content> patients studied, 76 had acute myocardial infarction (<jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>), 102 had unstable angina pectoris (<jats:styled-content style=\"fixed-case\">UAP<\/jats:styled-content>), and 46 had stable angina pectoris (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>). The levels of <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>\u2010positive (<jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>+) <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> were analysed by flow cytometry. The status of spotty calcification was determined by cardiac computed tomography angiography. <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> and calcium deposits were significantly increased in acute coronary artery syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) when compared with those in <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> patients. Positive correlation was also revealed between the number of <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> and the frequency of spotty calcification and levels of serum high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and serum alkaline phosphatase in <jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UAP<\/jats:styled-content> patients. In summary, the number of <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content> is positively related to the frequency of spotty calcification in <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> patients. Serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and serum alkaline levels are thought to contribute to the elevation of <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12366","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T08:17:32Z","timestamp":1422433052000},"page":"734-739","source":"Crossref","is-referenced-by-count":30,"title":["Correlation between osteocalcin\u2010positive endothelial progenitor cells and spotty calcification in patients with coronary artery disease"],"prefix":"10.1111","volume":"42","author":[{"given":"He","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology The Third Hospital of Shijiazhuang City Shijiazhuang 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