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Diethylcarbamazine (<jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content>) is a drug that has anti\u2010inflammatory properties due to its effects on the metabolism of arachidonic acid. The present study examined the anti\u2010inflammatory effects of <jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> on the mechanisms of alcoholic liver disease. C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 mice were divided into seven groups: (i) control; (ii) <jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> 50\u00a0mg\/kg; (iii) alcohol; (iv) alcohol\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> 50\u00a0mg\/kg; (v) alcohol\u00a0+\u00a0celecoxib 50\u00a0mg\/kg; (vi) alcohol\u00a0+\u00a0pyrrolidine dithiocarbamate 100\u00a0mg\/kg; and (vii) alcohol\u00a0+\u00a0pyrrolidine dithiocarbamate 100\u00a0mg\/kg\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> 50\u00a0mg\/kg. Liver fragments were stained with haemotoxylin\u2013eosin and Sirius red, and processed for immunofluorescence, western blot, and immunohistochemistry. Serum was also collected for biochemical measurements. Alcohol induced liver damage, elevated collagen content, and increased expression of nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells and inflammatory markers (tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>, interferon\u2010<jats:italic>\u03b3<\/jats:italic>, interleukin\u20101<jats:italic>\u03b2<\/jats:italic>, inducible nitric oxide synthase, cyclooxygenases\u20102, and transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic>). Treatment with <jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> was able to reduce liver damage, collagen content, the expression of nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells and inflammatory markers; it also ameliorated biochemistry parameters (total cholesterol, high\u2010density lipoprotein cholesterol, triglyceride content and aspartate aminotransferase) and increased the expression of anti\u2010inflammatory markers (p\u20105\u2032 adenosine monophosphate\u2010activated protein kinase and interleukin\u201010). Future clinical trials may demonstrate that oral administration of <jats:styled-content style=\"fixed-case\">DEC<\/jats:styled-content> may be suitable for the treatment of alcoholic liver disease and other liver diseases.<\/jats:p>","DOI":"10.1111\/1440-1681.12369","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T23:24:03Z","timestamp":1423783443000},"page":"369-379","source":"Crossref","is-referenced-by-count":9,"title":["Diethylcarbamazine: Possible therapeutic alternative in the treatment of alcoholic liver disease in C57<scp>BL<\/scp>\/6 mice"],"prefix":"10.1111","volume":"42","author":[{"given":"Gabriel Barros","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sura Wanessa Santos","family":"Rocha","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laise Aline Martins dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma Helena","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Oliveira dos Santos","family":"Gomes","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eduarda da Rocha","family":"de Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniele Bezerra","family":"L\u00f3s","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology (RENORBIO) Federal University of Pernambuco Pernambuco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Alves","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Ultrastructure Laboratory Institute Aggeu Magalh\u00e3es \u2010 FIOCRUZ Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01881.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i3.81"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00537.2010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1352.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03110.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2463"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2013.17"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/369693"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2006.00806.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.09.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2883-4-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000075351"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.03.046"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.012120"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/105120"},{"key":"e_1_2_8_21_1","first-page":"524","article-title":"Effects of diethylcarbamazine (DEC) on hepatocytes of C57BL\/6J mice submitted to protein malnutrition","volume":"20","author":"Rocha SWS","year":"2012","journal-title":"J. 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