{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:25Z","timestamp":1792787005807,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T00:00:00Z","timestamp":1429747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NH&MRC of Australia","award":["1067317"],"award-info":[{"award-number":["1067317"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Summary<\/jats:title>\n \n In mammals, colonic migrating motor complexes (\n CMMC<\/jats:styled-content>\n ) are a major propulsive contraction responsible for the expulsion of faecal content. Mice with a mutation of the endothelin\u20103 gene raised on a 129\n SL<\/jats:styled-content>\n background strain have ~70% colonic aganglionosis, lack\n CMMC<\/jats:styled-content>\n , and are lethal within 12\u00a0days postpartum. In contrast, endothelin\u20103 mutant mice raised and maintained on a C57\n BL<\/jats:styled-content>\n 6 background strain (lethal\u2010spotted (ls\/ls) mice) can live for much longer, but it is unclear whether\n CMMC<\/jats:styled-content>\n generation is preserved in these mice also lacking the endothelin\u20103 gene. The aim of this study was to determine whether\n CMMC<\/jats:styled-content>\n exist in ls\/ls mouse colon and, if so, whether their existence and frequency are related to the length of aganglionosis. Spatiotemporal mapping and mechanical recordings of colonic wall movements were made from isolated whole colons obtained from wild\u2010type and ls\/ls mice. Although ls\/ls mice had a megacolon, they still generated\n CMMC<\/jats:styled-content>\n in the ganglionic segment, which on some occasions could propagate short distances into the aganglionic region. There was large variability in aganglionosis length, which showed a weak correlation with the existence or frequency of\n CMMC<\/jats:styled-content>\n . Interestingly,\n CMMC<\/jats:styled-content>\n propagation velocity was slower in ls\/ls mice when evoked by intraluminal fluid. A myogenic motor pattern was identified in the aganglionic region that was maintained under tonic inhibition. We show that despite megacolon, ls\/ls mice still generate\n CMMC<\/jats:styled-content>\n in the ganglionic region. These offspring have sufficient propulsive motility in the ganglionic segment to live a normal murine lifespan and rarely die of bowel obstruction.\n <\/jats:p>","DOI":"10.1111\/1440-1681.12380","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T01:35:31Z","timestamp":1424741731000},"page":"485-495","source":"Crossref","is-referenced-by-count":9,"title":["Can colonic migrating motor complexes occur in mice lacking the endothelin\u20103 gene?"],"prefix":"10.1111","volume":"42","author":[{"given":"Kyra J","family":"Barnes","sequence":"first","affiliation":[{"name":"Discipline of Human Physiology Center for Neuroscience School of Medicine Flinders University of South Australia Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J","family":"Spencer","sequence":"additional","affiliation":[{"name":"Discipline of Human Physiology Center for Neuroscience School of Medicine Flinders University of South Australia Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703814"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00201-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015665"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1997.d01-25.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00444.2006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01076598"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00319.2011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00098"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.083600"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00558.2007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00420.2005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9592"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.107748"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10024-001-0142-y","article-title":"Enteric nervous system: Development and developmental disturbances\u2013part 1","volume":"5","author":"Newgreen D","year":"2002","journal-title":"Pediatr. 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