{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:31:08Z","timestamp":1777419068629,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Lipoprotein(a) (Lp(a)) is known to be associated with cardiovascular complications and atherothrombotic properties in general populations. However, it has not been examined whether Lp(a) levels are able to predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) with drug\u2010eluting stents (<jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content>). A total of 595 consecutive patients with angina pectoris who underwent elective <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> were enrolled from 2004 to 2010. The patients were divided into two groups according to the levels of Lp(a): Lp(a) &lt;\u00a050\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0485 patients), and Lp(a) \u2265\u00a050\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0111 patients). The 6\u20139\u2010month angiographic outcomes and 3\u2010year cumulative major clinical outcomes were compared between the two groups. Binary restenosis occurred in 26 of 133 lesions (19.8%) in the high Lp(a) group and 43 of 550 lesions (7.9%) in the low Lp(a) group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). In multivariate analysis, the reference vessel diameter, low density lipoprotein cholesterol, total lesion length, and Lp(a) \u2265\u00a050\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> were predictors of binary restenosis. In the Cox proportional hazards regression analysis, Lp(a) &gt;\u00a050\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> was significantly associated with the 3\u2010year adverse clinical outcomes including any myocardial infarction, revascularization (target lesion revascularization (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) and target vessel revascularization (<jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content>)), <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\u2010major adverse cardiac events (<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>s), <jats:styled-content style=\"fixed-case\">TVR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>, and All\u2010<jats:styled-content style=\"fixed-case\">MACE<\/jats:styled-content>s. In our study, high Lp(a) level \u2265\u00a050\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> in angina pectoris patients undergoing elective <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">DES<\/jats:styled-content> was significantly associated with binary restenosis and 3\u2010year adverse clinical outcomes in an Asian population.<\/jats:p>","DOI":"10.1111\/1440-1681.12396","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T06:36:52Z","timestamp":1428561412000},"page":"588-595","source":"Crossref","is-referenced-by-count":28,"title":["Impact of high lipoprotein(a) levels on in\u2010stent restenosis and long\u2010term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug\u2010eluting stents in Asian population"],"prefix":"10.1111","volume":"42","author":[{"given":"Sang\u2010Ho","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Soonchunhyang University Cheonan Hospital Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Woon","family":"Rha","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung\u2010Geol","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Eulji Medical University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Soonchunhyang University Cheonan Hospital Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Seog","family":"Seo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eung\u2010Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Korea University Guro Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Oh","family":"Na","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Korea University Guro Hospital Seoul 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