{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:22:49Z","timestamp":1773696169154,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Scientific Research Foundation of Department of Education, Liaoning Province","award":["L2012284"],"award-info":[{"award-number":["L2012284"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Peritoneal dialysis (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) is an effective treatment for patients with end\u2010stage renal diseases, but long\u2010term continuous <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> causes peritoneal fibrosis (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>). This study aims to evaluate the anti\u2010fibrotic effect of telmisartan on a rat model of <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> and to investigate the underlying mechanisms. Five\u2010sixths kidney nephrectomy and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were used to establish the <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> rat model. Glucose (2.5%) was used to establish an <jats:italic>in\u00a0vitro<\/jats:italic> model in rat peritoneal mesothelial cells (<jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>). Haematoxylin\u2013eosin staining was used to examine the structural alterations. Masson's trichrome staining was used to observe the tissue fibrosis in peritoneal membrane of rats. Real\u2010time polymerase chain reaction was used to measure messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expressions of profibrotic factors. Western blotting was used to determine protein expressions of profibrotic factors, peroxisome proliferator\u2010activated receptor\u2010<jats:italic>\u03b3<\/jats:italic>, and mitogen\u2010activated protein kinases (MAPK). Results demonstrated that administration of telmisartan dose\u2010dependently attenuated the thickening of the peritoneal membrane and the fibrosis induced by long\u2010term <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> fluid exposure in rats. In addition, telmisartan treatment inhibited the upregulation of profibrotic factors induced by <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> in the peritoneum of rats and by high\u2010concentration glucose in <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>. Telmisartan was also effective in inhibiting <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and high\u2010concentration, glucose\u2010induced phosphorylation of MAPK in the peritoneum and <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>. Furthermore, peroxisome proliferator\u2010activated receptor\u2010<jats:italic>\u03b3<\/jats:italic> (PPAR<jats:italic>\u03b3<\/jats:italic>) inhibitor <jats:styled-content style=\"fixed-case\">GW<\/jats:styled-content>9662 blocked these protective effects of telmisartan in <jats:styled-content style=\"fixed-case\">PMC<\/jats:styled-content>. The results suggest that telmisartan is effective in attenuating <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>, and this effect may be associated with the inhibition of profibrotic factor expression and MAPK phosphorylation via PPAR<jats:italic>\u03b3<\/jats:italic> activation.<\/jats:p>","DOI":"10.1111\/1440-1681.12403","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T08:33:01Z","timestamp":1428913981000},"page":"671-679","source":"Crossref","is-referenced-by-count":7,"title":["Telmisartan attenuates peritoneal fibrosis via peroxisome proliferator\u2010activated receptor\u2010<i>\u03b3<\/i> activation in rats"],"prefix":"10.1111","volume":"42","author":[{"given":"Xuesong","family":"Su","sequence":"first","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07920910"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132470"},{"issue":"2","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1177\/089686080902902S03","article-title":"Intrinsic cells: Mesothelial cells \u2013 central players in regulating inflammation and resolution","volume":"29","author":"Yung S","year":"2009","journal-title":"Perit. 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