{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:02Z","timestamp":1792788722796,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de Nivel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pr\u00f3-Reitoria de P\u00f3s-Gradua\u00e7\u00e3o da Universidade Federal de Minas Gerais"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effects of increased brain availability of <jats:sc>l<\/jats:sc>\u2010arginine (<jats:sc>l<\/jats:sc>\u2010arg), a precursor for nitric oxide synthesis, on core body temperature (<jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub>) and cutaneous heat loss were evaluated in running rats. One week prior to the experiments, adult male Wistar rats received the following implants: a chronic guide cannula in the lateral cerebral ventricle and a temperature sensor in the abdominal cavity. On the day of the experiments, the rats were assigned to receive a 2\u2010<jats:italic>\u03bc<\/jats:italic>L intracerebroventricular injection of either NaCl (0.15\u00a0mol\/L) or <jats:sc>l<\/jats:sc>\u2010arg solution (0.825, 1.65 or 3.30\u00a0mol\/L); <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> and tail skin temperature were measured while the rats ran at a speed of 18\u00a0m\/min until they were fatigued. <jats:sc>l<\/jats:sc>\u2010arginine induced a dose\u2010dependent reduction in the threshold <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> required for cutaneous heat loss (38.09\u00a0\u00b1\u00a00.20\u00b0C for 3.30\u2010mol\/L <jats:sc>l<\/jats:sc>\u2010arg <jats:italic>vs<\/jats:italic> 38.61\u00a0\u00b1\u00a00.10\u00b0C for saline; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), which attenuated the exercise\u2010induced hyperthermia. Although the rats treated with <jats:sc>l<\/jats:sc>\u2010arg presented a lower <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> at the end of exercise (~0.7\u00b0C lower after treatment with the highest dose), no changes in the time to fatigue were observed relative to the control trial. These results suggest that brain <jats:sc>l<\/jats:sc>\u2010arg controls heat loss during exercise, most likely by modulating the sympathetic vasoconstrictor tonus to skin vessels. Furthermore, despite facilitating cutaneous heat loss mechanisms, increased brain <jats:sc>l<\/jats:sc>\u2010arg availability did not enhance physical performance.<\/jats:p>","DOI":"10.1111\/1440-1681.12407","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T15:10:54Z","timestamp":1429197054000},"page":"609-616","source":"Crossref","is-referenced-by-count":26,"title":["Increased brain <scp>l<\/scp>\u2010arginine availability facilitates cutaneous heat loss induced by running exercise"],"prefix":"10.1111","volume":"42","author":[{"given":"Samuel Penna","family":"Wanner","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"},{"name":"Exercise Physiology Laboratory School of Physical Education, Physiotherapy and Occupational Therapy Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Hora Rios","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"},{"name":"Department of Physiology Institute of Biological Sciences Federal University of Juiz de Fora Juiz de Fora Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Bohnen","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"},{"name":"State\u00a0University of Minas Gerais Ibirit\u00e9 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e2ndido Celso","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biological Sciences Federal University of Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2011.587446"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05147.1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00391.2001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00722.2009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00503.2010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00206.2010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01713.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00046.2010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050361"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.3.1032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000100018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20143561"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)81719-2"},{"key":"e_1_2_6_15_1","first-page":"R967","article-title":"Role of the nitric oxide pathway in hypoxia\u2010induced hypothermia of rats","volume":"273","author":"Branco LG","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00423-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01345248"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.06.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.09.076"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","unstructured":"WannerSP LeiteLH MarubayashiU CoimbraCC.Evidence that brain L\u2010arginine availability modulates heat loss during physical exercise in rats. Experimental Biology 5\u20139 April 2008 San Diego CA.","DOI":"10.1096\/fasebj.22.1_supplement.956.12"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01173.2001"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(95)02020-R"},{"key":"e_1_2_6_23_1","first-page":"447","article-title":"The cerebral ventricles of the rat","volume":"108","author":"Levinger IM","year":"1971","journal-title":"J. Anat."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-198401000-00013"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/jappl.1978.44.4.571","article-title":"Colonic and tail\u2010skin temperature responses of the rat at selected running speeds","volume":"44","author":"Wilson NC","year":"1978","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1152\/jappl.1980.49.3.363","article-title":"Effects of apomorphine and pimozide on temperature regulation during exercise in the rat","volume":"49","author":"Gisolfi CV","year":"1980","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1152\/jappl.1985.59.5.1533","article-title":"Mode of neural control mediating rat tail vasodilation during heating","volume":"59","author":"O'Leary DS","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023770"},{"key":"e_1_2_6_29_1","first-page":"389","article-title":"Cardiovascular regulation by l\u2010arginine in the brain of rats: Role of the brain renin\u2010angiotensin system and nitric oxide","volume":"10","author":"Nishimura M","year":"1997","journal-title":"Am. J. Hypertens."},{"key":"e_1_2_6_30_1","first-page":"R864","article-title":"Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity","volume":"273","author":"Zhang K","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00338.2004"},{"key":"e_1_2_6_32_1","first-page":"35","article-title":"Central inhibition of nitric oxide synthesis increases blood pressure and heart rate in anesthetized rats","volume":"19","author":"Nurminen ML","year":"1997","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2743S"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66041683.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68031234.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.3.1055"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.5.2017"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00742.2003"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.110"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2012.01464.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2000.010003123.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1301"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007151"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2010.01206.x"},{"key":"e_1_2_6_45_1","volume-title":"The Rat Forebrain in Stereotaxic Coordinates","author":"Groot J","year":"1959"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.10.042"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01350.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.11.031"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.03.004"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.56.2.520"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:01:42Z","timestamp":1695549702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/1440-1681.12407"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12407","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}