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Certain drugs such as <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitors, <jats:styled-content style=\"fixed-case\">ANG II<\/jats:styled-content> antagonists, and even statins could interfere with the renin angiotensin system and modulate its deleterious effects. This study was carried out to investigate the possible role of losartan and atorvastatin in liver fibrosis. Liver fibrosis was induced in rats by i.p. injection of 50% <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> twice per week for 8\u00a0weeks. The rats intoxicated with <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> were divided into four groups: fibrosis control; losartan group; atorvastatin group; and co\u2010treated group. A fifth group of normal healthy rats served as a control group. The results showed that losartan and atorvastatin, either alone or in combination, significantly decreased <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AST<\/jats:styled-content>, hyaluronic acid and hydroxyproline levels in their groups compared to those of the fibrosis control group. A significant decrease in <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic> was found in the losartan and co\u2010treated groups but not in the atorvastatin group. These biochemical data were supported by liver histopathology and <jats:italic>\u03b1<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>. The results indicate that the combined treatment with both losartan and atorvastatin produced a greater effect than either drug alone and proved a beneficial role in inhibiting or reversing liver fibrosis.<\/jats:p>","DOI":"10.1111\/1440-1681.12446","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T17:45:09Z","timestamp":1436895909000},"page":"979-987","source":"Crossref","is-referenced-by-count":15,"title":["Antifibrotic effect of <scp>AT<\/scp>\u20101 blocker and statin in rats with hepatic fibrosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Nahla E","family":"El\u2010Ashmawy","sequence":"first","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda A","family":"El\u2010Bahrawy","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M","family":"Shamloula","sequence":"additional","affiliation":[{"name":"Pathology Department Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amera O","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Biochemistry Department Faculty of Pharmacy Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2011.010375"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66028"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.229.35"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1232"},{"key":"e_1_2_6_6_1","first-page":"169","article-title":"Serum hyaluronic acid and laminin as biomarkers in liver fibrosis","volume":"19","author":"Parsian H","year":"2010","journal-title":"J. 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