{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:13:10Z","timestamp":1787757190647,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The stress inducible 70 <jats:styled-content style=\"fixed-case\">kD<\/jats:styled-content>a heat shock protein (Hsp70) is instrumental to efficient morphological and functional recovery following skeletal muscle injury because of its roles in protein quality control and molecular signalling. Therefore, in attempt to improve recovery, Hsp70 expression was increased with 17\u2010(allylamino)\u201017\u2010demethoxygeldanamycin (17\u2010<jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>) prior to and following an intramuscular injection of barium chloride (BaCl<jats:sub>2<\/jats:sub>) into the tibialis anterior (<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>) of healthy young mice. To assess recovery, regenerating fibre cross\u2010sectional area (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>) of the <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> and <jats:italic>in\u00a0vivo<\/jats:italic> peak isometric torque produced by the anterior crural muscles (<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>, extensor digitorum longus and extensor hallucis muscles) were analyzed for up to 3\u00a0weeks after the injury. Because treatment of 17\u2010<jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content> and Hsp70 are known to influence inflammatory and myogenic signalling, tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) and myogenin content were also assessed. This study reports that 17\u2010<jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content> was effective at up\u2010regulating Hsp70 expression, increasing content fivefold in the uninjured muscle. However, this significant increase in Hsp70 content did not enhance morphological or functional recovery following the injury, as the return of regenerating fibre <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content> and <jats:italic>in\u00a0vivo<\/jats:italic> peak isometric torque did not differ compared to that of the injured muscle from the vehicle treated mice. Treatment with 17\u2010<jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content> also altered <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> and myogenin content, increasing both to a greater extent after the injury. Together, these findings demonstrate that although 17\u2010<jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content> may alter molecular makers of regeneration, it does not improve recovery following BaCl<jats:sub>2<\/jats:sub>\u2010induced skeletal muscle injury in healthy young mice.<\/jats:p>","DOI":"10.1111\/1440-1681.12477","type":"journal-article","created":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T10:02:18Z","timestamp":1439719338000},"page":"1308-1316","source":"Crossref","is-referenced-by-count":10,"title":["17\u2010(allylamino)\u201017\u2010demethoxygeldanamycin drives Hsp70 expression but fails to improve morphological or functional recovery in injured skeletal muscle"],"prefix":"10.1111","volume":"42","author":[{"given":"Cory W","family":"Baumann","sequence":"first","affiliation":[{"name":"Muscle Biology Laboratory Department of Kinesiology and Health Georgia State University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Otis","sequence":"additional","affiliation":[{"name":"Muscle Biology Laboratory Department of Kinesiology and Health Georgia State University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12081"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005368831198"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2002.32.2.58"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2348-8093.155515"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00032.2003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1419406"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00454.2004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00735.2009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2001.00795.x"},{"key":"e_1_2_6_12_1","first-page":"295","article-title":"Heat shock: The role of transient inducible responses in cell damage, transformation, and differentiation","volume":"3","author":"Morimoto R","year":"1991","journal-title":"Cancer Cells"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00028-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-110163"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2010_03_234"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00849.2010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705799105"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00315.2009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1291fje"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062687"},{"key":"e_1_2_6_21_1","first-page":"34","article-title":"Stress proteins and initiation of immune response: Chaperokine activity of hsp72","volume":"11","author":"Asea A","year":"2005","journal-title":"Exerc. 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