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However, much less often have these drugs been studied in relation to cardiovascular diseases. This brief review mainly describes the role of <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content> signalling in cardiovascular pathogenesis such as atherosclerosis, pulmonary arterial hypertension, diabetes, angiogenesis and inflammation with an emphasis on how <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>s function in these situations and what components might serve as potential therapeutic targets against cardio\u2010metabolic dysfunction.<\/jats:p>","DOI":"10.1111\/1440-1681.12478","type":"journal-article","created":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T09:59:23Z","timestamp":1439719163000},"page":"1221-1224","source":"Crossref","is-referenced-by-count":43,"title":["Targeting the platelet\u2010derived growth factor signalling in cardiovascular disease"],"prefix":"10.1111","volume":"42","author":[{"given":"Weining","family":"Hu","sequence":"first","affiliation":[{"name":"Shenzhen Research Institute Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Research Institute Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Structure and function of platelet\u2010derived growth factor (PDGF) and related proteins","volume":"989","author":"Hannink M","year":"1989","journal-title":"Biochim. 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