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The most serious problem after myocardial infarction is reperfusion injury that manifests as functional impairment, arrhythmia, and accelerated progression of cell death in certain critically injured myocytes. Subsequently the infarcted myocardium develops features of necrosis and reactive inflammation. To reduce lethal reperfusion injury in patient with<jats:styled-content style=\"fixed-case\">AMI<\/jats:styled-content>antioxidants, anti\u2010inflammatory agents, adenosine, opioids, metabolic modulators (glucose, insulin, and potassium, nicorandil and agents which reduce intracellular Ca<jats:sup>2+<\/jats:sup>overload and inhibit Na<jats:sup>+<\/jats:sup>\u2010H<jats:sup>+<\/jats:sup>exchange) are used. In this study a novel compound (compound 9) 1\u2010(1\u00a0h\u2010indol\u20104\u2010yloxy)\u20103\u2010{[2\u2010(2\u2010methoxyphenoxy) ethyl]amino}propan\u20102\u2010ol and its enantiomers are examined in arrhythmia associated with coronary artery occlusion and reperfusion in a rat model. Antioxidant properties are also determined for test compounds using the malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>) lipid peroxidation and ferric reducing antioxidant power (<jats:styled-content style=\"fixed-case\">FRAP<\/jats:styled-content>) tests. In summary, the tested compounds, especially the S enantiomer has a strong antiarrhythmic activity in a model of occlusion and reperfusion of the left coronary artery which is probably related to their adrenolytic action. In contrast to carvedilol, none of the test compound reduced the lipid peroxidation but increased ferric reducing antioxidant power. In the antioxidant effect, there was no difference between the optical forms of compound 9.<\/jats:p>","DOI":"10.1111\/1440-1681.12491","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T09:52:40Z","timestamp":1442656360000},"page":"81-87","source":"Crossref","is-referenced-by-count":0,"title":["Antiarrhythmic activity in occlusion\u2010reperfusion model of 1\u2010(1H\u2010indol\u20104\u2010yloxy)\u20103\u2010{[2\u2010(2\u2010methoxyphenoxy)ethyl]amino} propan\u20102\u2010ol and its enantiomers"],"prefix":"10.1111","volume":"43","author":[{"given":"Marek","family":"Bednarski","sequence":"first","affiliation":[{"name":"Department of Pharmacological Screening Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Screening Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Siwek","sequence":"additional","affiliation":[{"name":"Department of Pharmacobiology Faculty of Pharmacy Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Zygmunt","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Screening Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Knutelska","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Screening Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leszek","family":"Nowi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Groszek","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Rzesz\u00f3w University of Technology Rzesz\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Sapa","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Screening Jagiellonian University Medical College Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.07.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2005.03.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(09)70162-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.09.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.11.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.01.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.03.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(96)02854-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01073-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.1124"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2008.10.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.04.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2008.06.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.047"},{"key":"e_1_2_6_16_1","first-page":"88","article-title":"Antagonistic effects of \u03b1\u2010adrenoceptor blocking agents on arrhythmias, enzyme release, and myocardial necrosis in isolated rat hearts with coronary occlusion and reperfusion","volume":"338","author":"Bernauer M","year":"1998","journal-title":"Naunyn\u2010Schmiedeberg's Arch. 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