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In this study, acute foot\u2010shock stress was used in mice to investigate the involvement of the opioid pathway in the antidepressant\u2010like effect of the cannabinoid <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content><jats:sub>1<\/jats:sub> receptor inverse agonist <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251. Stress was induced by intermittent foot\u2010shock stimulation for 30\u00a0min. Then, using the forced swimming test (<jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>) and tail suspension test (<jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>), the immobility time was measured. Results show that the immobility time was significantly prolonged in animals subjected to foot\u2010shock stress,\u00a0compared\u00a0with\u00a0non\u2010stressed controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Also, the serum corticosterone level was significantly increased after stress induction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Administration of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251 (0.5 and 0.3\u00a0mg\/kg, intraperitoneally (i.p.)), significantly decreased the immobility time of stressed mice in the <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01, respectively) and <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). The lowest dose of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251 (0.1\u00a0mg\/kg), naltrexone (0.3\u00a0mg\/kg), and morphine (1.0\u00a0mg\/kg) did not show any significant effect on stressed animals (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). Co\u2010administration of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251 with sub\u2010effective dose of naltrexone decreased the effective dose of this cannabinoid inverse agonist, to 0.1\u00a0mg\/kg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). On the other hand, administration of the sub\u2010effective dose of morphine reversed the anti\u2010immobility effect of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251 (0.5\u00a0mg\/kg; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In conclusion, the present study for the first time reveals the possible role of opioid signalling in the antidepressant\u2010like properties of <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>\u2010251 in a foot\u2010shock stress model.<\/jats:p>","DOI":"10.1111\/1440-1681.12518","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T15:41:03Z","timestamp":1448552463000},"page":"203-212","source":"Crossref","is-referenced-by-count":30,"title":["Involvement of opioid system in antidepressant\u2010like effect of the cannabinoid <scp>CB<\/scp><sub>1<\/sub> receptor inverse agonist <scp>AM<\/scp>\u2010251 after physical stress in mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Sattar","family":"Ostadhadi","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Brain and Spinal Cord Injury Research Center Neuroscience Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya","family":"Haj\u2010Mirzaian","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Nikoui","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Kordjazy","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad\u2010Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Brain and Spinal Cord Injury Research Center Neuroscience Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1048-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.09.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200312000-00001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.032"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.10.006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00323-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.021"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.07.030"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25954.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.007"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1615\/CritRevNeurobiol.v13.i3.20","article-title":"Behavioural effects of cannabinoid agents in animals","volume":"13","author":"Chaperon F","year":"1998","journal-title":"Crit. 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