{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:02:47Z","timestamp":1760425367013},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001796","name":"University of the Sunshine Coast","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001796","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Abdominal aortic aneurysm (<jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>) is an inflammatory vascular disease. Long chain omega\u20103 polyunsaturated fatty acids (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s) decrease inflammation and oxidative stress in an angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010infused apolipoprotein E\u2010knockout (ApoE<jats:sup>\u2212\/\u2212<\/jats:sup>) mouse model of <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>. This study investigated the effects of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s on blood pressure and vascular reactivity in fourteen angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010infused ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> male mice. Blood pressure was obtained using a non\u2010invasive tail cuff method and whole blood was collected by cardiac puncture. Vascular reactivity of the thoracic aorta was assessed using wire myography and activation of endothelial nitric oxide synthase (<jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content>) was determined by immunohistochemistry. A high <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> diet increased the omega\u20103 index and reduced the n\u20106 to n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> ratio. At day 10 post\u2010infusion with angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, there was no difference in systolic blood pressure or diastolic blood pressure in mice fed the high or low n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> diets. The high <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> diet resulted in a non\u2010significant trend for delay in time to death from abdominal aortic rupture. Vascular reactivity and <jats:styled-content style=\"fixed-case\">eNOS<\/jats:styled-content> activation remained unchanged in mice fed the high compared to the low <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> diet. This study argues against direct improvement in vascular reactivity in ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice that were supplemented with n\u20103 <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> for 8\u00a0weeks prior to infusion with angiotensin II.<\/jats:p>","DOI":"10.1111\/1440-1681.12520","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T17:48:13Z","timestamp":1449596893000},"page":"174-181","source":"Crossref","is-referenced-by-count":10,"title":["Investigation of long chain omega\u20103 <scp>PUFA<\/scp>s on arterial blood pressure, vascular reactivity and survival in angiotensin <scp>II<\/scp>\u2010infused Apolipoprotein E\u2010knockout mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Corinna S","family":"B\u00fcrgin\u2010Maunder","sequence":"first","affiliation":[{"name":"Inflammation and Healing Research Cluster University of the Sunshine Coast Sippy Downs Queensland 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser D","family":"Russell","sequence":"additional","affiliation":[{"name":"Inflammation and Healing Research Cluster University of the Sunshine Coast Sippy Downs Queensland 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