{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:44:50Z","timestamp":1773297890151,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T00:00:00Z","timestamp":1458086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Panax notoginseng saponins (<jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>) are major components of Panax notoginseng, a herb with established clinical efficacy\u00a0against vascular diseases. <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.Z\u2010<jats:italic>Lepr<\/jats:italic><jats:sup><jats:italic>fa<\/jats:italic><\/jats:sup>\/IzmDmcr (<jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content>) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is mediated by nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>). This study investigated whether <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> and its components can ameliorate this vascular dysfunction in <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats. In an <jats:italic>in\u00a0vitro<\/jats:italic> study, in the presence or absence of <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> and its components, vasodilation in response to nitroprusside was determined from myographs under isometric tension conditions in aortas and mesenteric arteries from male <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats at 18\u201320\u00a0weeks of age. In an <jats:italic>in\u00a0vivo<\/jats:italic> study, <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> (30\u00a0mg\/kg per day) was orally administered to <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats from 8 to 20\u00a0weeks of age. <jats:italic>In vitro<\/jats:italic> treatment with <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> and Ginsenoside Rb<jats:sub>1<\/jats:sub> increased nitroprusside\u2010induced relaxation of aortas and mesenteric arteries in <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats. The <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>\u2010induced increase was not affected by a nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) synthase inhibitor or endothelium denudation. Relaxation in response to a cell\u2010permeable <jats:styled-content style=\"fixed-case\">cGMP<\/jats:styled-content> analogue was increased by <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">cGMP<\/jats:styled-content> accumulation by nitroprusside was not altered. <jats:italic>In vivo<\/jats:italic> treatment with <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats lowered blood pressure and increased relaxation and the expression of soluble guanylyl cyclase protein in arteries, without affecting metabolic abnormalities. These results indicate that <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> causes an increase in vasodilation in response to <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> and a decrease in blood pressure, resulting in protection against vascular dysfunction in <jats:styled-content style=\"fixed-case\">SHRSP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">ZF<\/jats:styled-content> rats. <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> might be beneficial in alleviating impaired vasodilation in metabolic syndrome.<\/jats:p>","DOI":"10.1111\/1440-1681.12547","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T16:44:12Z","timestamp":1453221852000},"page":"459-467","source":"Crossref","is-referenced-by-count":11,"title":["Panax notoginseng saponins ameliorate impaired arterial vasodilation in <scp>SHRSP<\/scp>.Z\u2010<i>Lepr<\/i><sup><i>fa<\/i><\/sup>\/lzmDmcr rats with metabolic syndrome"],"prefix":"10.1111","volume":"43","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianning","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Kagota","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy and Pharmaceutical Sciences Mukogawa Women's University Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy and Pharmaceutical Sciences Mukogawa Women's University Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Wakuda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy and Pharmaceutical Sciences Mukogawa Women's University Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Shinozuka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy and Pharmaceutical Sciences Mukogawa Women's University Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/204840"},{"key":"e_1_2_6_3_1","first-page":"1768","article-title":"Protective effect of the traditional Chinese medicine xuesaitong on intestinal ischemia\u2010reperfusion injury in rats","volume":"8","author":"Xu X","year":"2015","journal-title":"Int. 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