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Zaprinast (5\u00a0\u00d7\u00a010<jats:sup>\u22126<\/jats:sup>\u00a0mol\/L) and sildenafil (10<jats:sup>\u22126<\/jats:sup>\u00a0mol\/L), phosphodiesterase inhibitors, inhibited H<jats:sub>2<\/jats:sub>S\u2010induced relaxation. Adenylyl cyclase inhibitors<jats:italic>N<\/jats:italic>\u2010ethylmaleimide (2.5\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>\u00a0mol\/L) and<jats:styled-content style=\"fixed-case\">SQ<\/jats:styled-content>22536 (10<jats:sup>\u22124<\/jats:sup>\u00a0mol\/L) reduced relaxation to H<jats:sub>2<\/jats:sub>S. Also, H<jats:sub>2<\/jats:sub>S\u2010induced relaxation was reduced by<jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l (50\u00a0mmol\/L), 4\u2010aminopyridine (10<jats:sup>\u22123<\/jats:sup>\u00a0mol\/L), a K<jats:sub>v<\/jats:sub>inhibitor, glibenclamide (10<jats:sup>\u22125<\/jats:sup>\u00a0mol\/L), a<jats:styled-content style=\"fixed-case\">K<jats:sub>ATP<\/jats:sub><\/jats:styled-content>inhibitor or barium chloride (10<jats:sup>\u22125<\/jats:sup>\u00a0mol\/L), a<jats:styled-content style=\"fixed-case\">K<jats:sub>IR<\/jats:sub><\/jats:styled-content>inhibitor. However, H<jats:sub>2<\/jats:sub>S\u2010induced relaxation was not influenced by apamin (10<jats:sup>\u22126<\/jats:sup>\u00a0mol\/L), a<jats:styled-content style=\"fixed-case\">SK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub><jats:sup>2+<\/jats:sup>inhibitor, charybdotoxin (10<jats:sup>\u22127<\/jats:sup>\u00a0mol\/L), an<jats:styled-content style=\"fixed-case\">IK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub><jats:sup>2+<\/jats:sup>and<jats:styled-content style=\"fixed-case\">BK<jats:sub>C<\/jats:sub><\/jats:styled-content><jats:sub>a<\/jats:sub><jats:sup>2+<\/jats:sup>inhibitor or combination of apamin and charybdotoxin. Nifedipine (10<jats:sup>\u22126<\/jats:sup>\u00a0mol\/L), an L\u2010type calcium channel blocker and atropine (10<jats:sup>\u22126<\/jats:sup>\u00a0mol\/L), a muscarinic receptor blocker, inhibited H<jats:sub>2<\/jats:sub>S\u2010induced relaxation. However, H<jats:sub>2<\/jats:sub>S\u2010induced relaxation was not influenced by ouabain (10<jats:sup>\u22124<\/jats:sup>\u00a0mol\/L), a Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase inhibitor. This study suggests that H<jats:sub>2<\/jats:sub>S endogenously synthesizes from<jats:sc>l<\/jats:sc>\u2010cysteine by<jats:styled-content style=\"fixed-case\">CSE<\/jats:styled-content>endothelium\u2010dependent in mouse corpus cavernosum tissue, and exogenous H<jats:sub>2<\/jats:sub>S may cause endothelium\u2010independent relaxations via activation of K channels (<jats:styled-content style=\"fixed-case\">K<jats:sub>ATP<\/jats:sub><\/jats:styled-content>channel,<jats:styled-content style=\"fixed-case\">K<jats:sub>V<\/jats:sub><\/jats:styled-content>channels,<jats:styled-content style=\"fixed-case\">K<jats:sub>IR<\/jats:sub><\/jats:styled-content>channels), L\u2010type voltage\u2010gated Ca<jats:sup>2+<\/jats:sup>channels, adenylyl cyclase\/<jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>pathway and muscarinic receptor, and there is the interaction between H<jats:sub>2<\/jats:sub>S and<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">cGMP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12554","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T18:22:13Z","timestamp":1454610133000},"page":"503-511","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of relaxant mechanism of H<sub>2<\/sub>S in mouse corpus cavernosum"],"prefix":"10.1111","volume":"43","author":[{"given":"Fatma","family":"Aydinoglu","sequence":"first","affiliation":[{"name":"Department of Pharmacology Pharmacy Faculty \u00c7ukurova University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuran","family":"Ogulener","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Medical Faculty \u00c7ukurova University Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp111"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0510-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12084"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.176016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18144-8_3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02617.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 protects against\u00a0myocardial ischemia\u00a0and\u00a0reperfusion\u00a0injury by attenuating oxidative stress and apoptosis in rats","volume":"29","author":"Meng G","year":"2015","journal-title":"J. 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