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Muscle loss has been attributed to a variable combination of reduced nutritional intake and an imbalance between anabolic and catabolic processes. It has been suggested that defective skeletal muscle regeneration may also contribute to muscle wasting in cancer patients. However, there is little <jats:italic>in\u00a0vitro<\/jats:italic> or <jats:italic>in\u00a0vivo<\/jats:italic> data available, in either animals or in humans, regarding skeletal muscle regeneration in cancer wasting. The aim of the present review is to define the role of skeletal muscle regeneration in the muscle wasting of cancer patients and to determine possible therapeutic implications.<\/jats:p>","DOI":"10.1111\/1440-1681.12559","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T11:42:38Z","timestamp":1455018158000},"page":"522-527","source":"Crossref","is-referenced-by-count":29,"title":["Skeletal muscle regeneration in cancer cachexia"],"prefix":"10.1111","volume":"43","author":[{"given":"Maurizio","family":"Bossola","sequence":"first","affiliation":[{"name":"Department of Surgery Catholic University of the Sacred Heart School of Medicine  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Marzetti","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Neurosciences and Orthopedics Catholic University of the Sacred Heart School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Surgery Catholic University of the Sacred Heart School of Medicine  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pacelli","sequence":"additional","affiliation":[{"name":"Department of Surgery Catholic University of the Sacred Heart School of Medicine  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2010.10.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/182872"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.16.8.1241"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21893"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.12.023"},{"key":"e_1_2_10_8_1","first-page":"779","article-title":"Muscle regeneration: Cellular and molecular events","volume":"23","author":"Karalaki M","year":"2009","journal-title":"In Vivo"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00032"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0098-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200701027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05312.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.6.2295"},{"key":"e_1_2_10_14_1","first-page":"391","article-title":"TNF inhibits myogenesis and downregulates the expression of myogenic regulatory factors myoD and myogenin","volume":"74","author":"Szalay K","year":"1997","journal-title":"Eur. 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