{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T04:04:28Z","timestamp":1748837068598,"version":"3.41.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Scientific Research (B)","award":["22390304"],"award-info":[{"award-number":["22390304"]}]},{"name":"Japan Society for Promotion of the Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The action of angiotensin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>(Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) on the Ca<jats:sup>2+<\/jats:sup>signals driving pyeloureteric peristalsis was investigated using both conventional and angiotensin receptor (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r)<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A and<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2 knockout (<jats:sup>\u2212\/\u2212<\/jats:sup>) mice. Contractility in the renal pelvis of adult<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>and<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>\u2212\/\u2212<\/jats:sup>mice was compared to their respective wildtype (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>+\/+<\/jats:sup>and<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>+\/+<\/jats:sup>) controls of the same genetic background (<jats:styled-content style=\"fixed-case\">FVB<\/jats:styled-content>\/N and C57Bl\/6 respectively) using video microscopy. The effects of Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>on the Ca<jats:sup>2+<\/jats:sup>signals in typical and atypical smooth muscle cells (<jats:styled-content style=\"fixed-case\">TSMC<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">ASMC<\/jats:styled-content>s, respectively) within the pelvic wall of conventional mice were recorded using Fluo\u20104 Ca<jats:sup>2+<\/jats:sup>imaging. Compared to\u00a0<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>+\/+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>+\/+<\/jats:sup>and<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>\u2212\/\u2212<\/jats:sup>mice, kidneys of the<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>mouse were mildly\u2010to\u2010severely hydronephrotic, associated with an enlarged calyx, an atrophic papilla and a hypoplastic renal pelvis. Contraction frequencies in the renal pelvis of moderately hydronephrotic<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>and unaffected<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>\u2212\/\u2212<\/jats:sup>mice were not significantly different from their<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>+\/+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>+\/+<\/jats:sup>controls. No contractions were observed in severely\u2010hydronephrotic<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>kidneys. Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>increased the spontaneous contraction frequency of the renal pelvis in<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>+\/+<\/jats:sup>,<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>+\/+<\/jats:sup>and<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r2<jats:sup>\u2212\/\u2212<\/jats:sup>mice, but had little effect on the contractions in the mildly\u2010hydronephrotic<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>renal pelvis. The<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1 blocker, candesartan prevented the positive chronotropic effects of Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Ang<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>increased the frequency and synchronicity of Ca<jats:sup>2+<\/jats:sup>transients in both<jats:styled-content style=\"fixed-case\">TSMC<\/jats:styled-content>s and<jats:styled-content style=\"fixed-case\">ASMC<\/jats:styled-content>s. It was concluded that the hydronephrosis observed in<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>r1A<jats:sup>\u2212\/\u2212<\/jats:sup>mouse kidneys does not arise from a failure in the development of the essential pacemaker and contractile machinery driving pyeloureteric peristalsis.<\/jats:p>","DOI":"10.1111\/1440-1681.12560","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T08:33:19Z","timestamp":1455525199000},"page":"535-542","source":"Crossref","is-referenced-by-count":6,"title":["Angiotensin receptor\u20101A knockout leads to hydronephrosis not associated with a loss of pyeloureteric peristalsis in the mouse renal pelvis"],"prefix":"10.1111","volume":"43","author":[{"given":"Michael J","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Physiology School of Biomedical Sciences Monash University Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Hashitani","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Biomedical Sciences Monash University Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"The renal pelvis: Machinery that concentrates urine in the papilla","volume":"8","author":"Dwyer TM","year":"2003","journal-title":"News Physiol. 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