{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:24:34Z","timestamp":1775885074638,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501408"],"award-info":[{"award-number":["81501408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lupus nephritis (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) is a highly complex autoimmune disease caused by systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>). Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) play a vital role in the pathogenesis of <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>. Previously, a total of 29 mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were identified to be down\u2010regulated in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients, in which miR\u2010410 was likely to be involved in the signalling transduction pathways in regulating the pathogenesis of <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>. The purpose of this study was to investigate the role of miR\u2010410 in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> and to find out whether miR\u2010410 regulates the expression of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20106 and fibrosis in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>. It was found that the expression level of miR\u2010410 in kidney tissue of <jats:styled-content style=\"fixed-case\">MRL<\/jats:styled-content>\/lpr mice was decreased compared to that in <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/C mice, whereas the level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 was overexpressed in <jats:styled-content style=\"fixed-case\">MRL<\/jats:styled-content>\/lpr mice. Luciferase assay showed that miR\u2010410 binds directly to the 3\u2032 untranslated region (<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, with the results showing that overexpression of miR\u2010410 significantly decreased the expression level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">MES<\/jats:styled-content>13 cells. Moreover, overexpression of miR\u2010410 significantly reduced the expression levels of fibrosis factors such as transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic>1 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1) and collagen I\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">MES<\/jats:styled-content>13 cells; Inhibition of the expression of miR\u2010410 with miR\u2010410 inhibitor resulted in increased levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 as well as fibrosis factors. The results identify that miR\u2010410, as a novel and critical factor in the pathogenesis of <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>, decreases <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 expression by binding directly to the 3\u2032<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> and suppresses fibrosis through down\u2010regulation of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010<jats:italic>\u03b2<\/jats:italic>1 in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">MES<\/jats:styled-content>13 cells. Our study brings new insight into understanding the complex mechanisms involved in the pathogenesis of lupus disease.<\/jats:p>","DOI":"10.1111\/1440-1681.12576","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:11:33Z","timestamp":1459383093000},"page":"616-625","source":"Crossref","is-referenced-by-count":31,"title":["miR\u2010410 suppresses the expression of interleukin\u20106 as well as renal fibrosis in the pathogenesis of lupus nephritis"],"prefix":"10.1111","volume":"43","author":[{"given":"Dongmei","family":"Liu","sequence":"first","affiliation":[{"name":"The First Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Department of Rheumatology and Immunology Shengjing Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.08.018"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60279-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0511-OA"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.88"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3611"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.121"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5590-1_1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920209788185252"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60889-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.02.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022681"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu1023oa"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9104-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315588971"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059557"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090401"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00050"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2009.08.012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0000000000000085"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.022"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/527895"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.06.027"},{"key":"e_1_2_7_28_1","first-page":"58","article-title":"Expression of interleukin 6 and major histocompatibility complex molecules in tubular epithelial cells of diseased human kidneys","volume":"69","author":"Fukatsu A","year":"1993","journal-title":"Lab. Invest."},{"key":"e_1_2_7_29_1","first-page":"61","article-title":"Distribution of interleukin\u20106 in normal and diseased human kidney","volume":"65","author":"Fukatsu A","year":"1991","journal-title":"Lab. Invest."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00191429"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02433.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/3.3.273"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38818"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1273rev"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011010055"},{"key":"e_1_2_7_37_1","first-page":"276","article-title":"[Migration and health: notes on an interdisciplinary field of research]","volume":"29","author":"Frenk J","year":"1987","journal-title":"Salud Publica Mex."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010020134"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/314318b0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0892"},{"key":"e_1_2_7_41_1","first-page":"3994","article-title":"miR\u2010144 regulates transforming growth factor\u2010beta1 iduced hepatic stellate cell activation in human fibrotic liver","volume":"8","author":"Liu Z","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045663"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0075"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.5.7946384"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302470"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206478"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb07031.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.12.1461"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12576","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:58:41Z","timestamp":1695560321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,4]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/1440-1681.12576"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12576","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,4]]}}}