{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:55:05Z","timestamp":1793246105494,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003007","name":"Egyptian Ministry of Scientific Research","doi-asserted-by":"crossref","award":["12-2-4"],"award-info":[{"award-number":["12-2-4"]}],"id":[{"id":"10.13039\/501100003007","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several chronic liver diseases can lead to the occurrence of hepatic fibrosis through the accumulation of iron, which causes induction of oxidative stress and consequently activation of fibrogenesis. The present study was designed to investigate the potential antifibrotic and anti\u2010oxidant effects of deferoxamine (<jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content>), a well\u2010known iron chelator in an experimental rat model of liver injury using carbon tetrachloride (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>). First, the potential effective dose of <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> was screened against <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010induced acute hepatotoxicity. Then, rats were co\u2010treated with <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> (300\u00a0mg\/kg, i.p.) for 6\u00a0weeks starting from the third week of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub> induction of chronic hepatotoxicity. Liver function was assessed in addition to histopathological examination. Furthermore, oxidative stress and fibrosis markers were assessed. It was found that treatment of animals with <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> significantly counteracted the changes in liver function; histopathological lesions and hepatic iron deposition that were induced by <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>. <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> also significantly counteracted the <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010induced lipid peroxidation increase and reduction in antioxidant activities of superoxide dismutase and glutathione peroxidase enzymes. In addition, <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> ameliorated significantly liver fibrosis markers including hydroxyproline, collagen accumulation, and the expression of the hepatic stellate cells (<jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s) activation marker; alpha smooth muscle actin and transforming growth factor\u2010beta (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2). Together, these findings indicate that <jats:styled-content style=\"fixed-case\">DFO<\/jats:styled-content> possesses a potent antifibrotic effect due to its antioxidant properties that counteracted oxidative stress and lipid peroxidation and restored antioxidant enzymes activities as well as reducing <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s activation and fibrogenesis.<\/jats:p>","DOI":"10.1111\/1440-1681.12591","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T17:34:43Z","timestamp":1462988083000},"page":"760-768","source":"Crossref","is-referenced-by-count":34,"title":["Deferoxamine alleviates liver fibrosis induced by <scp>CC<\/scp>l<sub>4<\/sub> in rats"],"prefix":"10.1111","volume":"43","author":[{"given":"Aya","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy Al\u2010Azhar University Cairo 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