{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:29Z","timestamp":1792003169321,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Neurokinin A (<jats:styled-content style=\"fixed-case\">NKA<\/jats:styled-content>) is a peptide neurotransmitter that participates in the regulation of breathing and the cardiovascular system. The purpose of the current study was to determine the cardiorespiratory pattern exerted by the systemic injection of NKA, to look at the contribution of neurokinin<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>1<\/jats:sub>and<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>2<\/jats:sub>receptors, and to establish the engagement of the vagal pathway in mediation of these responses. The effects of intravenous injections of<jats:styled-content style=\"fixed-case\">NKA<\/jats:styled-content>(50\u00a0\u03bcg\/kg) were studied in anaesthetized, spontaneously breathing rats in the following experimental schemes: in neurally intact rats; and vagotomized at either midcervical or supranodosal level. Intravenous injections of<jats:styled-content style=\"fixed-case\">NKA<\/jats:styled-content>in the intact rats evoked sudden and short\u2010lived increase in the respiratory rate concomitant with drop in tidal volume, followed by a prolonged depression, coupled with continuous augmentation of the tidal volume. Respiratory alterations were accompanied by transient tachycardia and prolonged hypotension. Midcervical vagotomy eliminated respiratory rate response and augmentation of tidal volume. Section of supranodosal vagi abrogated all respiratory reactions.<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>2<\/jats:sub>receptor blockade abolished respiratory changes without affecting cardiovascular effects, whereas<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>1<\/jats:sub>receptor blockade significantly reduced hypotension and increase in heart rate with no impact on the respiratory system. These results indicate that<jats:styled-content style=\"fixed-case\">NKA<\/jats:styled-content>induced changes in the breathing resulting from an excitation of the<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>2<\/jats:sub>receptors on the vagal endings. A fall in blood pressure triggered by<jats:styled-content style=\"fixed-case\">NKA<\/jats:styled-content>occurs outside of the vagus nerve and is probably mediated<jats:italic>via<\/jats:italic>its direct action on vascular smooth muscles supplied with<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content><jats:sub>1<\/jats:sub>receptors.<\/jats:p>","DOI":"10.1111\/1440-1681.12594","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T15:02:07Z","timestamp":1463842927000},"page":"818-824","source":"Crossref","is-referenced-by-count":8,"title":["The role of vagal pathway and<scp>NK<\/scp><sub>1<\/sub>and<scp>NK<\/scp><sub>2<\/sub>receptors in cardiovascular and respiratory effects of neurokinin A"],"prefix":"10.1111","volume":"43","author":[{"given":"Katarzyna","family":"Kaczy\u0144ska","sequence":"first","affiliation":[{"name":"Laboratory of Respiration Physiology Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Jampolska","sequence":"additional","affiliation":[{"name":"Laboratory of Respiration Physiology Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Szereda\u2010Przestaszewska","sequence":"additional","affiliation":[{"name":"Laboratory of Respiration Physiology Mossakowski Medical Research Centre Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1474-8673.2002.00262.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06295.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.6.L1348"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.039"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2014-0008"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1152\/jappl.1990.69.6.1981","article-title":"Central action of tachykinins on activity of expiratory pumping muscles","volume":"69","author":"Haxhiu MA","year":"1990","journal-title":"J Appl Physiol (1985)"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9903091"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00112.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2001.0361"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.6.R1803"},{"key":"e_1_2_5_13_1","first-page":"253","article-title":"Neurokinin A and B: potent vasodilators in the canine forelimb","volume":"6","author":"Dobbins DE","year":"1990","journal-title":"Microcirc Endothelium Lymphatics"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-3565(24)37103-4","article-title":"Bronchoconstrictor and respiratory effects of neurokinin A in dogs","volume":"283","author":"Sherwood JE","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1992.sp003607"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.114314"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00952.2003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1517"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.55782\/ane-2000-1333","article-title":"Respiratory effects of capsaicin occur beyond the lung vagi in anaesthetized rats","volume":"60","author":"Kaczy\u0144ska K","year":"2000","journal-title":"Acta Neurobiol Exp"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.33549\/physiolres.932412","article-title":"Nodose ganglia\u2010modulatory effects on respiration","volume":"62","author":"Kaczy\u0144ska K","year":"2013","journal-title":"Physiol Res"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021371"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1523\/JNEUROSCI.17-20-07683.1997","article-title":"Allergic inflammation in isolated vagal sensory ganglia unmasks silent NK\u20102 tachykinin receptors","volume":"17","author":"Weinreich D","year":"1997","journal-title":"J Neurosci"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.1.51"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.5_Pt_1.1177"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb12763.x"},{"key":"e_1_2_5_26_1","first-page":"25","article-title":"Neurokinin receptors in recurrent airway obstruction: a comparative study of affected and unaffected horses","volume":"73","author":"Venugopal CS","year":"2009","journal-title":"Can J Vet Res"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.10.029"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0022-3565(24)37167-8","article-title":"Effects of tachykinins on rapidly adapting pulmonary stretch receptors and total lung resistance in anesthetized, artificially ventilated rabbits","volume":"283","author":"Matsumoto S","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.56.030194.000441"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00203-6"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00794-4"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1988.tb03302.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00260610"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90081-6"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(93)90305-H"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2003"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703135"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12594","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T17:47:43Z","timestamp":1748972863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/1440-1681.12594"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12594","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]}}}