{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:22:46Z","timestamp":1761988966852},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study investigated the alteration of voltage\u2010dependent K<jats:sup>+<\/jats:sup> (Kv) channels in mesenteric arterial smooth muscle cells from control (Long\u2010Evans Tokushima Otsuka [<jats:styled-content style=\"fixed-case\">LETO<\/jats:styled-content>]) and diabetic (Otsuka Long\u2010Evans Tokushima Fatty [<jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content>]) rats during the early and chronic phases of diabetes. We demonstrated alterations in the mesenteric Kv channels during the early and chronic phase of diabetes using the patch\u2010clamp technique, the arterial tone measurement system, and <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in Long\u2010Evans Tokushima (LETO; for control) and Otsuka Long\u2010Evans Tokushima Fatty (OLETF; for diabetes) type 2 diabetic model rats. In the early phase of diabetes, the amplitude of mesenteric Kv currents induced by depolarizing pulses was greater in <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats than in <jats:styled-content style=\"fixed-case\">LETO<\/jats:styled-content> rats. The contractile response of the mesenteric artery induced by the Kv inhibitor, 4\u2010aminopyridine (4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>), was also greater in <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats. The expression of most Kv subtypes\u2010 including Kv1.1, Kv1.2, Kv1.4, Kv1.5, Kv1.6, Kv2.1, Kv3.2, Kv4.1, Kv4.3, Kv5.1, Kv6.2, Kv8.1, Kv9.3, and Kv10.1\u2010were increased in mesenteric arterial smooth muscle from <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats compared with <jats:styled-content style=\"fixed-case\">LETO<\/jats:styled-content> rats. However, in the chronic phase of diabetes, the Kv current amplitude did not differ between <jats:styled-content style=\"fixed-case\">LETO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats. In addition, the 4\u2010<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010induced contractile response of the mesenteric artery and the expression of Kv subtypes did not differ between the two groups. The increased Kv current amplitude and Kv channel\u2010related contractile response were attributable to the increase in Kv channel expression during the early phase of diabetes. The increased Kv current amplitude and Kv channel\u2010related contractile response were reversed during the chronic phase of diabetes.<\/jats:p>","DOI":"10.1111\/1440-1681.12599","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T20:16:12Z","timestamp":1464120972000},"page":"808-817","source":"Crossref","is-referenced-by-count":9,"title":["Alterations of voltage\u2010dependent K<sup>+<\/sup> channels in the mesenteric artery during the early and chronic phases of diabetes"],"prefix":"10.1111","volume":"43","author":[{"given":"Da Hye","family":"Hong","sequence":"first","affiliation":[{"name":"Institute of Medical Sciences Department of Physiology Kangwon National University School of Medicine  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences Department of Physiology Kangwon National University School of Medicine 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