{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:50:38Z","timestamp":1788929438372,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NT\/14012\u20103\/2013"],"award-info":[{"award-number":["NT\/14012\u20103\/2013"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023001"],"award-info":[{"award-number":["00023001"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["#CZ.2.16\/3.1.00\/28025"],"award-info":[{"award-number":["#CZ.2.16\/3.1.00\/28025"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Summary<\/jats:title>The role of hypertension and the renin\u2010angiotensin system (RAS<\/jats:styled-content>) in sex\u2010related differences in the course of chronic kidney disease (CKD<\/jats:styled-content>) and congestive heart failure (CHF<\/jats:styled-content>) remain unclear, especially when the two diseases are combined. In male and female Ren\u20102 transgenic rats (TGR<\/jats:styled-content>), a model of hypertension with activation of endogenous RAS<\/jats:styled-content>, CKD<\/jats:styled-content> was induced by 5\/6 renal mass reduction (5\/6 NX<\/jats:styled-content>) and CHF<\/jats:styled-content> was elicited by volume overload achieved by creation of an aorto\u2010caval fistula (ACF<\/jats:styled-content>). The primary aim of the study was to examine long\u2010term CKD<\/jats:styled-content>\u2010 and CHF<\/jats:styled-content>\u2010related mortality, especially in animals with CKD<\/jats:styled-content> and CHF<\/jats:styled-content> combined, with particular interest in the potential sex\u2010related differences. The follow\u2010up period was 23\u00a0weeks after the first intervention (5\/6 NX<\/jats:styled-content>). We found, first, that TGR<\/jats:styled-content> did not exhibit sexual dimorphism in the course of 5\/6 NX<\/jats:styled-content>\u2010induced CKD<\/jats:styled-content>. Second, in contrast, TGR<\/jats:styled-content> exhibited important sex\u2010related differences in the course of ACF<\/jats:styled-content>\u2010induced CHF<\/jats:styled-content>\u2010related mortality: intact female TGR<\/jats:styled-content> showed higher survival rate than male TGR<\/jats:styled-content>. This situation is reversed in the course of combined 5\/6 NX<\/jats:styled-content>\u2010induced CKD<\/jats:styled-content> and ACF<\/jats:styled-content>\u2010induced CHF<\/jats:styled-content>\u2010related mortality: intact female TGR<\/jats:styled-content> exhibited poorer survival than male TGR<\/jats:styled-content>. Third, the survival rate in animals with combined 5\/6 NX<\/jats:styled-content>\u2010induced CKD<\/jats:styled-content> and ACF<\/jats:styled-content>\u2010induced CHF<\/jats:styled-content> was significantly worsened as compared with rat groups that were exposed to \u2018single organ disease\u2019. Collectively, our present results clearly show that CKD<\/jats:styled-content> aggravates long\u2010term mortality of animals with CHF<\/jats:styled-content>. In addition, TGR<\/jats:styled-content> exhibit remarkable sexual dimorphism with respect to CKD<\/jats:styled-content>\u2010 and CHF<\/jats:styled-content>\u2010related mortality, especially in animals with combined CKD<\/jats:styled-content> and CHF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12619","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T14:52:58Z","timestamp":1467816778000},"page":"883-895","source":"Crossref","is-referenced-by-count":15,"title":["Sex\u2010linked differences in the course of chronic kidney disease and congestive heart failure: a study in 5\/6 nephrectomized Ren\u20102 transgenic hypertensive rats with volume overload induced using aorto\u2010caval fistula"],"prefix":"10.1111","volume":"43","author":[{"given":"Lud\u011bk","family":"\u010cervenka","sequence":"first","affiliation":[{"name":"Centre for Experimental Medicine Institute for Clinical and Experimental Medicine Prague Czech 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