{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:40:23Z","timestamp":1787013623628,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2013023021"],"award-info":[{"award-number":["2013023021"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The present study investigates the ameliorating effects of emodin on acute lung injury (\n                    <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n                    ) induced by severe acute pancreatitis (\n                    <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>\n                    ). An\n                    <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>\n                    rat model was constructed by sodium ursodeoxycholate and they were divided into four groups: SHAM, ALI, emodin and dexamethasone (DEX) (n=24 per group). Blood samples and lung tissues were collected 6, 12 and 24\u00a0hours after the induction of SAP\u2010associated ALI. Lung wet\/dry ratio, blood gases, serum amylase and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were measured at each time point. The expressions of AQP1 and AQP5 in lung tissue were detected by immunohistochemical staining, western blotting and real\u2010time PCR. As the results show, there were no statistical differences in the levels of serum amylase, lung wet\/dry ratio, blood gases indexes, serum TNF\u2010\u03b1 and pathological changes between emodin and DEX groups. However, significant differences were observed when compared with the ALI group. AQP1 and AQP5 expressions were significantly increased and lung oedemas were alleviated with the treatment of emodin and DEX. The expressions of AQP1 and AQP5 were significantly decreased in SAP\u2010associated ALI rats. Emodin up\u2010regulated the expression of AQP1 and AQP5, it could reduce pulmonary oedema and ameliorate SAP\u2010induced ALI. Regulations on AQP1 and AQP5 expression had a great value in clinical application.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.12627","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T07:53:17Z","timestamp":1469433197000},"page":"1071-1079","source":"Crossref","is-referenced-by-count":35,"title":["Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up\u2010regulated expressions of AQP1 and AQP5 in lung"],"prefix":"10.1111","volume":"43","author":[{"given":"Junfeng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of General Surgery the First People's Hospital of Xiaoshan District of Hangzhou City  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyu","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[{"name":"VIP Ward No. 2 the Second Hospital of Dalian Medical University  Dalian 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