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Mechanical stretch increases cellular Na<jats:sup>+<\/jats:sup> inflow, activates the reverse mode of the Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup> exchanger, and modifies Ca<jats:sup>2+<\/jats:sup> handling and myocardial electrophysiology, favoring arrhythmogenesis. This study aims to determine whether <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 modifies the stretch\u2010induced manifestations of mechanoelectric feedback. The ventricular fibrillation (<jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content>) modifications induced by acute stretch were studied in Langendorff\u2010perfused rabbit hearts using epicardial multiple electrodes under control conditions (n=9) or during <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 perfusion: 0.1\u00a0\u03bcmol\/L (n=9) and 1\u00a0\u03bcmol\/L (n=9). Spectral and mapping techniques were used to establish the baseline, stretch and post\u2010stretch <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> characteristics. <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 slowed baseline <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> and decreased activation complexity. These effects were dose\u2010dependent (baseline <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> dominant frequency: control=13.9\u00b12.2\u00a0Hz; <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content> 0.1\u00a0\u03bcmol\/L=11.1\u00b11.1\u00a0Hz, <jats:italic>P<\/jats:italic>&lt;.01; <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content> 1\u00a0\u03bcmol\/L=6.6\u00b11.1\u00a0Hz, <jats:italic>P&lt;<\/jats:italic>.0001). The stretch\u2010induced acceleration of <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> (control=38.8%) was significantly reduced by <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 0.1\u00a0\u03bcmol\/L (19.8%) and abolished by <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content> 1\u00a0\u03bcmol\/L (\u22121.5%). During stretch, the <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> activation complexity index was reduced in both <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 series (control=1.60\u00b10.15; <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content> 0.1\u00a0\u03bcmol\/L=1.13\u00b10.3, <jats:italic>P&lt;<\/jats:italic>.0001; <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content> 1\u00a0\u03bcmol\/L=0.57\u00b10.21, <jats:italic>P&lt;<\/jats:italic>.0001), and was independently related to <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> dominant frequency (<jats:italic>R<\/jats:italic>=.82; <jats:italic>P&lt;<\/jats:italic>.0001). The fifth percentile of the <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> activation intervals, conduction velocity and wavelength entered the multiple linear regression model using dominant frequency as the dependent variable (<jats:italic>R<\/jats:italic>=\u2212.84; <jats:italic>P&lt;<\/jats:italic>.0001). In conclusion, <jats:styled-content style=\"fixed-case\">JTV<\/jats:styled-content>\u2010519 slowed and simplified the baseline <jats:styled-content style=\"fixed-case\">VF<\/jats:styled-content> activation patterns and abolished the stretch\u2010induced manifestations of mechanoelectric feedback.<\/jats:p>","DOI":"10.1111\/1440-1681.12630","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T18:16:18Z","timestamp":1470680178000},"page":"1062-1070","source":"Crossref","is-referenced-by-count":3,"title":["Effects of <scp>JTV<\/scp>\u2010519 on stretch\u2010induced manifestations of mechanoelectric feedback"],"prefix":"10.1111","volume":"43","author":[{"given":"Irene","family":"del Canto","sequence":"first","affiliation":[{"name":"Department of Medicine Valencia University \u201cEstudi General\u201d  Valencia 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