{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:48:19Z","timestamp":1784180899927,"version":"3.55.0"},"reference-count":73,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Accumulating data advocates that inflammatory mediators may contribute to depression in experimental models as well as in humans. Nonetheless, whether anti\u2010inflammatory treatments can prevent depression still remains controversial. To substantiate our hypothesis, we used an interferon\u2010\u03b1\u20102b model of depression using Sprague Dawley rats. Interferon\u2010\u03b1\u20102b is a cytokine which activates immune response and also produces depression. The animals were treated for 21\u00a0days with aspirin (10\u00a0mg\/kg, per oral (p.o.)) dexamethasone (1\u00a0mg\/kg p.o.) and amitriptyline (10\u00a0mg\/kg p.o.). Amitriptyline was used as reference standard, and given concurrently with aspirin and dexamethasone to examine any synergy. Interferon\u2010\u03b1\u20102b (6000\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/kg, intraperitoneal (i.p.)) was administered in all the above groups daily, except normal control. Tests performed included sucrose preference test, behavioural tests like forced swim test, elevated plus maze, light dark box and locomotor activity along with biochemical estimations like serum cortisol and brain neurotransmitters. The rats in the group treated with Interferon\u2010\u03b1\u20102b produced depressive behaviour in rats. We found that animals treated with aspirin decreased immobility time in forced swim test, increased sucrose preference, decreased serum cortisol and increased brain serotonin levels signifying antidepressant action. In contrast, there was no effect in groups treated with dexamethasone. Our results suggest that aspirin can serve as a potential antidepressant both individually and as adjuvant agent in the treatment of depression. Inhibition of the cyclo\u2010oxygenase\u20102 levels and prostaglandins concentration or any other potential physiological and biochemical mechanisms may be involved in antidepressant effect.<\/jats:p>","DOI":"10.1111\/1440-1681.12660","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T13:07:29Z","timestamp":1472130449000},"page":"1208-1215","source":"Crossref","is-referenced-by-count":9,"title":["Beneficial effect of aspirin against interferon\u2010\u03b1\u20102b\u2014induced depressive behavior in Sprague Dawley rats"],"prefix":"10.1111","volume":"43","author":[{"given":"Shailendra","family":"Bhatt","sequence":"first","affiliation":[{"name":"L J Institute of Pharmacy Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kilambi","family":"Pundarikakshudu","sequence":"additional","affiliation":[{"name":"L J Institute of Pharmacy Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Patel","sequence":"additional","affiliation":[{"name":"L J Institute of Pharmacy Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Patel","sequence":"additional","affiliation":[{"name":"L J Institute of Pharmacy Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Panchal","sequence":"additional","affiliation":[{"name":"L J Institute of Pharmacy Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurang","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology K B Institute of Pharmaceutical Education and Research Gandhinagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Pharmacology L M College of Pharmacy Navrangpura Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61415-9"},{"key":"e_1_2_6_3_1","first-page":"A22","article-title":"Depression as a major component of public health for older adults","volume":"5","author":"Chapman DP","year":"2008","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00528.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0022-3565(24)39013-5","article-title":"Antidepressant\u2010like behavioral effects mediated by 5\u2010Hydroxytryptamine(2C) receptors","volume":"295","author":"Cryan JF","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-200"},{"key":"e_1_2_6_8_1","first-page":"355","article-title":"Effects of intracerebroventricular administration of bradykinin on rat brain serotonin and prostaglandins","volume":"54","author":"Bhattacharya SK","year":"1986","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212757"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0478-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00166981"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/039463201002300204","article-title":"The effect of newer serotonin\u2010noradrenalin antidepressants on cytokine production: a review of the current literature","volume":"23","author":"Berardis D","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1667"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.03.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.11.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05886.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.12.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-012-9348-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.01.017"},{"key":"e_1_2_6_21_1","first-page":"12","article-title":"Chronic intestinal inflammation alters hippocampal neurogenesis","volume":"3","author":"Zonis S","year":"2015","journal-title":"J Neuroinflammation"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1623-07.2007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.01.012"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.3.327"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.04.011"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.07.041"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.03.013"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285611406166"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.03.008"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102412"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0208"},{"key":"e_1_2_6_32_1","first-page":"49","article-title":"Using non\u2010steroidal anti\u2010inflammatory drugs in the treatment of depression","volume":"22","author":"Davis A","year":"2010","journal-title":"Psychiatr Danub"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.036"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.05.005"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.86815"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000192087.64432.ae"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.014"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.023"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02235-0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.01.050"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(00)00051-2"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00324-4"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.05.015"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62858-X"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02260.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.09.010"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.01.014"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.180.2.99"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00051-4"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015912800604533"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000643"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(95)00524-2"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7449-4"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.07.015"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001805"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.11.006"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.79"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.05.058"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.05.035"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-74"},{"key":"e_1_2_6_61_1","first-page":"2","article-title":"Hyperforin, an anti\u2010inflammatory constituent from St. John's wort, inhibits microsomal prostaglandin E2 synthase\u20101 and suppresses prostaglandin E2 formation in vivo","volume":"18","author":"Koeberle A","year":"2011","journal-title":"Front Pharmacol"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210902010001"},{"key":"e_1_2_6_63_1","first-page":"37","article-title":"Alzheimer's disease: fatty acids we eat may be linked to a specific protection via low\u2010dose aspirin","volume":"1","author":"Pomponi MF","year":"2010","journal-title":"Aging Dis"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.2.249"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.05.010"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1978.tb07751.x"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187257"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(78)90118-8"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.10.002"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(81)90007-1"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-077"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.91154"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00293.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(74)90235-4"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T14:01:32Z","timestamp":1749564092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,21]]},"references-count":73,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/1440-1681.12660"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12660","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,21]]}}}