{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T07:28:00Z","timestamp":1697095680797},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Science and Technology Project of the Science and Technology Department of Hunan Province","award":["2012WK2002"],"award-info":[{"award-number":["2012WK2002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to investigate the effects of renal sympathetic denervation (<jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>) on blood pressure, renal function, and renal tissue pathological changes in obesity\u2010induced hypertensive dogs. Thirty\u2010two beagle dogs (10\u201012\u00a0months) were randomized to the control (n=10) and model groups (n=22). High\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) was used to establish the obesity\u2010induced hypertensive model. After 3\u00a0months of <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>, 20 animals with successfully induced hypertension were randomized to the <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> (n=10) and sham groups (n=10). Renal artery angiography, body weight, blood pressure, heart rate (HR), and blood and urine biochemistry were determined 1, 3 and 6\u00a0months after surgery. Models were killed 6\u00a0months after surgery. Pathological changes in the renal artery and renal tissue were assessed. The <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> group had significantly (<jats:italic>P<\/jats:italic>&lt;.05) increased body weight, HR, and blood pressure, and higher levels of urine albumin, serum noradrenaline, and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> compared with controls. After <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content>, blood pressure was decreased compared with baseline and the sham group (<jats:italic>P<\/jats:italic>&lt;.05). In the <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> group, examination of the renal artery and renal tissue showed intact intima of renal artery in the surgical area, renal sympathetic nerve degeneration, necrosis, and dissolution, and widened space between nerve fibres. Hypertension\u2010induced renal pathological changes were mild to moderate in the <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> group, but severe in the sham group. The control group had normal glomerular structure. In conclusion, <jats:styled-content style=\"fixed-case\">RDN<\/jats:styled-content> can effectively lower blood pressure in obesity\u2010induced hypertensive dogs, as well as hypertension\u2010induced renal pathological changes.<\/jats:p>","DOI":"10.1111\/1440-1681.12661","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T13:16:57Z","timestamp":1472131017000},"page":"1213-1223","source":"Crossref","is-referenced-by-count":6,"title":["Renal simplicity denervation reduces blood pressure and renal injuries in an obesity\u2010induced hypertension dog model"],"prefix":"10.1111","volume":"44","author":[{"given":"Zhihui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology the Third Xiangya Hospital of Central South University Hypertension Research Center of Hunan Province  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology the Third Xiangya Hospital of Central South University Hypertension Research Center of Hunan Province  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology the Third Xiangya Hospital of Central South University Hypertension Research Center of Hunan Province  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology the Third Xiangya Hospital of Central South University Hypertension Research Center of Hunan Province  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of 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