{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:35:19Z","timestamp":1789205719767,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Continuous positive airway pressure (<jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>) improves autonomic activity in patients with chronic heart failure (<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>) and central sleep apnoea (<jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>), but its effect on heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>) during therapy has not been reported. We hypothesized that <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> may decrease <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>, despite its beneficial effects on sympathetic overactivation, due to the expected stabilization of breathing. Sixty\u2010seven <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> patients underwent polysomnography (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>). Ten of them presented with <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content> (age 66.1\u00b18.5\u00a0years, apnoea\u2010hypopnea index [<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>]=57.6\u00b123.3, central <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">cAHI<\/jats:styled-content>]=41.6\u00b124.6 [mean\u00b1<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>]) and were subjected to a second <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content> with manual <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> titration. Beat\u2010to\u2010beat heart intervals for a 6\u2010hour period of sleep were extracted from each recording and <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> was analysed. <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> significantly reduced <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>=23.1\u00b118.3 <jats:italic>P<\/jats:italic>=.004). Standard deviation of normal\u2010normal interbeat interval (<jats:styled-content style=\"fixed-case\">SDNN<\/jats:styled-content>) (61.5\u00b129.0 vs 49.5\u00b119.3\u00a0ms, <jats:italic>P<\/jats:italic>=.021), root mean square of successive differences (<jats:styled-content style=\"fixed-case\">RMSSD<\/jats:styled-content>) (21.8\u00b19.2 vs 16.4\u00b17.1\u00a0ms, <jats:italic>P<\/jats:italic>=.042), total power (ln<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>=7.8\u00b11.1 vs 7.4\u00b10.8\u00a0ms<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>=.037), low frequency power (ln<jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>=5.5\u00b11.5 vs 5.0\u00b11.4\u00a0ms<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>=.003) and high frequency power (ln<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>=4.6\u00b11.0 vs 4.0\u00b11.0\u00a0ms<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>=.024) were decreased. There was a strong correlation between the decrease in <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> and the decrease in ln<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> (Spearman's \u03c1=.782). <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content> leads to a decrease in spectral and time domain parameters of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> during therapy in <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>. These changes are best explained by the effect which <jats:styled-content style=\"fixed-case\">CPAP<\/jats:styled-content>\u2010influenced breathing pattern and lowered <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content> exert on <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1440-1681.12662","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T13:29:36Z","timestamp":1472131776000},"page":"1185-1190","source":"Crossref","is-referenced-by-count":10,"title":["The effect of continuous positive airway pressure on heart rate variability during the night in patients with chronic heart failure and central sleep apnoea"],"prefix":"10.1111","volume":"43","author":[{"given":"Kiril V","family":"Terziyski","sequence":"first","affiliation":[{"name":"Pathophysiology Department Medical University \u2013 Plovdiv  Plovdiv Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneliya 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