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Different factors contribute to the progression of chronic kidney disease, including glomerular sclerosis, atherosclerosis of the renal arteries and tubulointerstitial fibrosis. Tubulointerstitial injury is induced by hypoxia and other inflammatory signals, leading to fibroblast activation. Technological advances using high\u2010throughput sequencing has enabled the determination of the expression profile of almost all genes, revealing that gene expression is intricately regulated by <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation, histone modification, changes in chromosome conformation, long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s. These epigenetic modifications are stored as cellular epigenetic memory. Epigenetic memory leads to adult\u2010onset disease or ageing in the long term and may possibly play an important role in the kidney disease process. Herein we emphasize the importance of clarifying the molecular mechanisms underlying epigenetic modifications because this may lead to the development of new therapeutic targets in kidney disease.<\/jats:p>","DOI":"10.1111\/1440-1681.12663","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T13:27:50Z","timestamp":1472131670000},"page":"1159-1167","source":"Crossref","is-referenced-by-count":18,"title":["New insights into molecular mechanisms of epigenetic regulation in kidney disease"],"prefix":"10.1111","volume":"43","author":[{"given":"Imari","family":"Mimura","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrinology The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology The University of Tokyo  Tokyo 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