{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:45:48Z","timestamp":1767116748627},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\/hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) co\u2010infection is likely to be associated with an increased risk of kidney disease, due to the additional factors that may affect renal function in the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> population. We aimed to evaluate renal toxicity in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> mono\u2010infected patients on long\u2010term therapy with tenofovir (<jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>) and to explore the association of polymorphisms in <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>\u2010binding cassette (<jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content><\/jats:italic>)<jats:italic>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>4<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>10<\/jats:italic> with the development of renal dysfunction. From September 2006 to November 2014, 44 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> co\u2010infected and 34 <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> mono\u2010infected patients were commenced on <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>. Data of renal safety were retrospectively collected and analyzed. <jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>4<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>10<\/jats:italic> genotypes were identified by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Over 60\u00a0months of observation, there was a significant increase in mean creatinine levels from baseline (<jats:italic>P<\/jats:italic>&lt;.01) that was not significantly different between the two study groups. Moreover, a significant decline in estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) was observed from baseline (<jats:italic>P<\/jats:italic>&lt;.01), and it was significantly greater in <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> mono\u2010infected than co\u2010infected patients (<jats:italic>P<\/jats:italic>=.03). The distribution of <jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>4<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ABCC<\/jats:styled-content>10<\/jats:italic> genotypes among a subgroup of 34 patients did not show significant association with <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> decline &lt;90\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min per 1.73\u00a0m<jats:sup>2<\/jats:sup>. Although our findings showed a statistically significant decrease in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> with long\u2010term use of <jats:styled-content style=\"fixed-case\">TDF<\/jats:styled-content>, its clinical impact seems to be modest. The role of genetic factors to identify patients at greater risk for developing tenofovir\u2010induced renal toxicity needs to be further investigated.<\/jats:p>","DOI":"10.1111\/1440-1681.12691","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T13:25:59Z","timestamp":1478179559000},"page":"191-196","source":"Crossref","is-referenced-by-count":11,"title":["Renal function in <scp>HIV<\/scp>\/<scp>HBV<\/scp> co\u2010infected and <scp>HBV<\/scp> mono\u2010infected patients on a long\u2010term treatment with tenofovir in real life setting"],"prefix":"10.1111","volume":"44","author":[{"given":"Laura","family":"Milazzo","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gervasoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. Sacco University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia Stefania","family":"Falvella","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pharmacology L. Sacco University Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pharmacology L. Sacco University Hospital  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mazzali","sequence":"additional","affiliation":[{"name":"Department of Management, Economics and Industrial Engineering Milan Politecnico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ronzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences L. 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