{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:46:26Z","timestamp":1775504786451,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T00:00:00Z","timestamp":1485216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2015R1D1A1A01056607"],"award-info":[{"award-number":["2015R1D1A1A01056607"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2016R1D1A1B03931625"],"award-info":[{"award-number":["2016R1D1A1B03931625"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The regulatory effect of \u03b2\u2010eudesmol, which is an active constituent of Pyeongwee\u2010San (<jats:styled-content style=\"fixed-case\">KMP<\/jats:styled-content>6), is evaluated for allergic reactions induced by mast cell degranulation. Phorbol 12\u2010myristate 13\u2010acetate (<jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content>) plus calcium ionophore A23187\u2010stimulated human mast cell line,<jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>\u20101 cells, and compound 48\/80\u2010stimulated rat peritoneal mast cells (<jats:styled-content style=\"fixed-case\">RPMC<\/jats:styled-content>s) are used as the in vitro models; mice models of systemic anaphylaxis, ear swelling, and IgE\u2010dependent passive cutaneous anaphylaxis (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) are used as the in vivo allergic models. The results demonstrate that \u03b2\u2010eudesmol suppressed the histamine and tryptase releases from the<jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content>plus calcium ionophore A23187\u2010stimulated<jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>\u20101 cells. \u03b2\u2010eudesmol inhibits the expression and activity of histidine decarboxylase in the activated<jats:styled-content style=\"fixed-case\">HMC<\/jats:styled-content>\u20101 cells. In addition, \u03b2\u2010eudesmol inhibits the levels of histamine and tryptase released from the compound 48\/80\u2010stimulated<jats:styled-content style=\"fixed-case\">RPMC<\/jats:styled-content>s. Furthermore, \u03b2\u2010eudesmol decreases the intracellular calcium level in the activated<jats:styled-content style=\"fixed-case\">RPMC<\/jats:styled-content>s. \u03b2\u2010eudesmol also decreases the compound 48\/80\u2010induced mortality and ear swelling response. \u03b2\u2010eudesmol suppresses the serum levels of histamine, IgE, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101\u03b2,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106,<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013, and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) under<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>mice as well as<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>reactions. Therefore, the results from this study indicate the potential of \u03b2\u2010eudesmol as an anti\u2010allergic drug with respect to its pharmacological properties against mast cell\u2010mediated allergic reactions.<\/jats:p>","DOI":"10.1111\/1440-1681.12698","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T16:48:40Z","timestamp":1479314920000},"page":"257-265","source":"Crossref","is-referenced-by-count":29,"title":["\u03b2\u2010eudesmol suppresses allergic reactions via inhibiting mast cell degranulation"],"prefix":"10.1111","volume":"44","author":[{"given":"Na\u2010Ra","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil\u2010Dong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka\u2010Jung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Bum","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Inflammatory Disease Research Centre Hoseo University Asan Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Ja","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology and Research Institute for Basic Science Hoseo University Asan Chungnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00646.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.09.007"},{"key":"e_1_2_7_4_1","volume-title":"Immunobiology: The Immune System in Health and Disease","author":"Janeway CA","year":"2001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20012037"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002619"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-3565(24)37586-X","article-title":"A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase","volume":"286","author":"He S","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9533-9_5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70181-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.049585"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.3.230"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.2.131"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01405.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.10.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2014-S01"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b05841"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2010.491082"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12354"},{"key":"e_1_2_7_19_1","volume-title":"Ocular Surface: Anatomy and Physiology, Disorders and Therapeutic Care","author":"Herranz RM","year":"2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.279"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.074"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.10.066"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.3854"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(14)60069-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-210"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2755"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90293-B"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80223-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02663-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20174"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162603"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00275802"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706246"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200501111"},{"key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3565(24)35267-X","article-title":"Compound 48\/80 activates mast cell phospholipase D via heterotrimeric GTP\u2010binding proteins","volume":"292","author":"Chahdi A","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3379"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.600932"},{"key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0022-3565(25)23159-7","article-title":"Enhancing effect by nicotinic acetylcholine receptor channel blockers, including beta\u2010eudesmol, on succinylcholine\u2010induced inhibition of twitch tension and intracellular Ca++ in mouse diaphragm muscle","volume":"256","author":"Kimura I","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180318697"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02452.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917351"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90107-D"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70140-X"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.43"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4049\/jimmunol.156.2.424","article-title":"Polymorphic nucleotides within the human IL\u20104 promoter that mediate overexpression of the gene","volume":"156","author":"Song Z","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"53.2","DOI":"10.4049\/jimmunol.196.Supp.53.2","article-title":"The synthesis of VEGF in allergen\u2010stimulated mast cells is through a leukotriene B4 receptor\u20102\u2010dependent signaling pathway","volume":"196","author":"Lee AJ","year":"2016","journal-title":"J Immunol"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar70"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2015.15884"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2010.522194"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.08.015"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.09.007"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2011.587128"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4727"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.07.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.02.035"},{"key":"e_1_2_7_56_1","first-page":"94","article-title":"Inhibitory effect of Gamibojungikgitang extract on mast cell\u2010mediated allergic reaction in murine model","volume":"8","author":"Moon PD","year":"2005","journal-title":"J Pharm Pharm Sci"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247194"},{"key":"e_1_2_7_58_1","first-page":"141","article-title":"Evaluation of antidepressant activity of vanillin in mice","volume":"5","author":"Shoeb A","year":"2013","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)00143-8"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02508.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.03.052"},{"key":"e_1_2_7_62_1","first-page":"e24","article-title":"A comparison of the effects of dexamethasone\u2010pharmacopuncture and dexamethasone\u2010oral administration based on traditional Korean medicine theory on anaphylactic reaction in mice","volume":"3","author":"Kim J","year":"2013","journal-title":"TANG"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:39:48Z","timestamp":1749746388000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,24]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/1440-1681.12698"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12698","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,24]]}}}