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We have investigated whether the offspring from mothers given 0.3\u00a0mol\/L NaCl show an ineffective angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> action to increase in blood pressure. It was hypothesized that functional alterations at adult life are associated with the number of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010positive cells in the developing kidney, with increased oxidative stress in maternal\/foetal organs, or with morphometrical changes in placentas. Wistar female rats were maintained on 0.3\u00a0mol\/L NaCl in their drinking water from 20\u00a0days before conception until weaning. After weaning, some of the male offspring were treated with enalapril for 21\u00a0days. Glomerular filtration rate was recorded up to 210\u00a0days of age, when mean arterial pressure was measured after infusion of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. To investigate the placenta and foetal kidneys, mothers on tap water or NaCl were also treated with alpha\u2010tocopherol, pregnancy being interrupted on the 20th day. There were no changes in the number of cells positive for angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> in the foetal kidney and unchanged lipid peroxidation in the placenta of offspring exposed to NaCl, but the intermediate trophoblast area in the junctional zone was increased, possibly reducing maternal\u2013foetal exchange. Glomerular filtration rate was reduced and there was an attenuated effect of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> on elevation of blood pressure, which could be mediated by an elevated angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> during early life, once these disturbances had been prevented by early and short\u2010term treatment with enalapril.<\/jats:p>","DOI":"10.1111\/1440-1681.12702","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T08:22:42Z","timestamp":1479543762000},"page":"275-284","source":"Crossref","is-referenced-by-count":3,"title":["Maternal Na<sup>+<\/sup> intake induces renal function injury in rats prevented by a short\u2010term angiotensin converting enzyme inhibitor"],"prefix":"10.1111","volume":"44","author":[{"given":"Natalie E","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Department of Morphology and Animal Physiology Federal Rural 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