{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:59:03Z","timestamp":1778893143572,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CIAFEL\u2010 UID\/DTP\/00617\/2013"],"award-info":[{"award-number":["CIAFEL\u2010 UID\/DTP\/00617\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/DTP\u2010DES\/7087\/2014 \u2010 POCI\u201001\u20100145\u2010FEDER\u2010016690"],"award-info":[{"award-number":["PTDC\/DTP\u2010DES\/7087\/2014 \u2010 POCI\u201001\u20100145\u2010FEDER\u2010016690"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/89807\/2012"],"award-info":[{"award-number":["SFRH\/BD\/89807\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/DTP\/00617\/2013"],"award-info":[{"award-number":["UID\/DTP\/00617\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/DTP\u2010DES\/7087\/2014"],"award-info":[{"award-number":["PTDC\/DTP\u2010DES\/7087\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI\u201001\u20100145\u2010FEDER\u2010016690"],"award-info":[{"award-number":["POCI\u201001\u20100145\u2010FEDER\u2010016690"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/89807\/2012"],"award-info":[{"award-number":["SFRH\/BD\/89807\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI10\/01677"],"award-info":[{"award-number":["FIS PI10\/01677"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/00515"],"award-info":[{"award-number":["PI12\/00515"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/01430"],"award-info":[{"award-number":["PI13\/01430"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>We aimed to investigate the effects of two physical exercise models, voluntary physical activity (VPA<\/jats:styled-content>) and endurance training (ET<\/jats:styled-content>) as preventive and therapeutic strategies, respectively, on lipid accumulation regulators and mitochondrial content in VAT<\/jats:styled-content> of rats fed a high\u2010fat diet (HFD<\/jats:styled-content>). Sprague\u2010Dawley rats (6\u00a0weeks old, n=60) were assigned into sedentary and VPA<\/jats:styled-content> groups fed isoenergetic diets: standard (S, 35\u00a0kcal% fat) or HFD<\/jats:styled-content> (71\u00a0kcal% fat). The VPA<\/jats:styled-content> groups had free access to wheel running during the entire protocol. After 9\u00a0weeks, half of the sedentary animals were exercised on a treadmill while maintaining the dietary treatments. The HFD<\/jats:styled-content> induced no changes in plasma non\u2010esterified fatty acids (NEFA<\/jats:styled-content>) and glycerol levels and decreased oxidative phosphorylation (OXPHOS<\/jats:styled-content>) subunit IV<\/jats:styled-content> and increased truncated\/full\u2010length sterol regulatory element\u2010binding transcription factor 1c (SREBP<\/jats:styled-content>1c) ratio in epididymal white adipose tissue (eWAT<\/jats:styled-content>). VPA<\/jats:styled-content> decreased plasma glycerol levels, aquaglyceroporin 7 (AQP<\/jats:styled-content>7) and increased subunit I of cytochrome c oxidase (COX<\/jats:styled-content>) protein, in standard diet fed animals. Eight weeks of ET<\/jats:styled-content> decreased body weight, visceral adiposity and adipocyte size and plasma NEFA<\/jats:styled-content> and glycerol levels, as well as AQP<\/jats:styled-content>7 protein expression in eWAT<\/jats:styled-content>. ET<\/jats:styled-content> increased fatty acid translocase (FAT<\/jats:styled-content>\/CD<\/jats:styled-content>36), mitochondrial content of complexes IV<\/jats:styled-content> and V subunits, mitochondrial biogenesis and dynamic (mitofusins and optic atrophy 1)\u2010related proteins. Moreover, lipogenesis\u2010related markers (SREBP<\/jats:styled-content>1c and acetyl CoA carboxylase) were reduced after 8\u00a0weeks of ET<\/jats:styled-content>. In conclusion, ET<\/jats:styled-content>\u2010induced alterations reflect a positive effect on mitochondrial function and the overall VAT<\/jats:styled-content> metabolism of HFD<\/jats:styled-content>\u2010induced obese rats.<\/jats:p>","DOI":"10.1111\/1440-1681.12706","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T05:49:26Z","timestamp":1479793766000},"page":"386-394","source":"Crossref","is-referenced-by-count":32,"title":["Physical exercise remodels visceral adipose tissue and mitochondrial lipid metabolism in rats fed a high\u2010fat diet"],"prefix":"10.1111","volume":"44","author":[{"given":"S\u00edlvia","family":"Rocha\u2010Rodrigues","sequence":"first","affiliation":[{"name":"CIAFEL \u2010 Research Centre in Physical Activity, Health and Leisure Faculty of Sport University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratory Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Obesity & Adipobiology Group Instituto de Investigaci\u00f3n Sanitario de Navarra (IdiSNA) Pamplona Spain"},{"name":"CIBEROBN Instituto de Salud Carlos III Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Becerril","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratory Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Obesity & Adipobiology Group Instituto de Investigaci\u00f3n Sanitario de Navarra (IdiSNA) Pamplona Spain"},{"name":"CIBEROBN Instituto de Salud Carlos III Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratory Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Obesity & Adipobiology Group Instituto de Investigaci\u00f3n Sanitario de Navarra (IdiSNA) Pamplona Spain"},{"name":"CIBEROBN Instituto de Salud Carlos III Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas O","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CIAFEL \u2010 Research Centre in Physical Activity, Health and Leisure Faculty of Sport University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Beleza","sequence":"additional","affiliation":[{"name":"CIAFEL \u2010 Research Centre in Physical Activity, Health and Leisure Faculty of Sport University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Fr\u00fchbeck","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratory Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Obesity & Adipobiology Group Instituto de Investigaci\u00f3n Sanitario de Navarra (IdiSNA) Pamplona Spain"},{"name":"CIBEROBN Instituto de Salud Carlos III Pamplona Spain"},{"name":"Department of Endocrinology & Nutrition Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Ascens\u00e3o","sequence":"additional","affiliation":[{"name":"CIAFEL \u2010 Research Centre in Physical Activity, Health and Leisure Faculty of Sport University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"CIAFEL \u2010 Research Centre in Physical Activity, Health and Leisure Faculty of Sport University of Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095442241400002X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.10.15672"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.07.080"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-008-9453-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-206862"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1937"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00271.2013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90408.2008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.172601"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1135"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1421"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.03.012"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092753"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/473430"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040876"},{"key":"e_1_2_7_18_1","first-page":"2935","article-title":"Effect of insulin on adipocyte lipolysis in exercise\u2010trained rats","volume":"1993","author":"Suda K","year":"1985","journal-title":"J Appl Physiol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508921735"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/21623945.2014.955423"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.269.6.E1059"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.165464"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00806.2010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2003.01164.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29044"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00297.2015"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1408"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2015-0470"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21170"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-012-0430-1"},{"issue":"2","key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.33549\/physiolres.932792","article-title":"Three months of regular aerobic exercise in patients with obesity improve systemic subclinical inflammation without major influence on blood pressure and endocrine production of subcutaneous fat","volume":"63","author":"Trachta P","year":"2014","journal-title":"Physiol Res"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi400914c"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.238451"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20354"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003826200"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414222200"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.111484"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.01.039"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212754200"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.03.010"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"}],"container-title":["Clinical and Experimental Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1440-1681.12706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1440-1681.12706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:50:03Z","timestamp":1696294203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1440-1681.12706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/1440-1681.12706"],"URL":"https:\/\/doi.org\/10.1111\/1440-1681.12706","archive":["Portico"],"relation":{},"ISSN":["0305-1870","1440-1681"],"issn-type":[{"value":"0305-1870","type":"print"},{"value":"1440-1681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}