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Lysosomal malfunction including storage disorders is involved in the pathogenesis of Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). Given the unclear molecular mechanisms of diverse defects in<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>phenotypes, especially behavioural deficits, this mini review explores the cellular contexts of<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>impulse control disorders and the molecular aspects of lysosomal cross\u2010membrane transports. Focuses are paid to trace metal involvements in \u03b1\u2010synuclein assembly in Lewy bodies, the functions and molecular interactions of<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>13A2 as<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase transporters in lysosomal membranes for cross\u2010membrane trafficking and lysosomal homeostasis, and our current understandings of the neural circuits in<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>. Erroneously polarized distributions of cargos such as metals and lipids on each side of lysosomal membranes triggered by gene mutations and deregulated expression of<jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>13A2 may thus instigate sensing protein structural changes such as aggregations, organelle degeneration, and specific neuronal ageing and death in Parkinsonism.<\/jats:p>","DOI":"10.1111\/1440-1681.12714","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T19:56:39Z","timestamp":1482263799000},"page":"172-179","source":"Crossref","is-referenced-by-count":4,"title":["Impulse control disorder, lysosomal malfunction and<scp>ATP<\/scp>13A2 insufficiency in Parkinsonism"],"prefix":"10.1111","volume":"44","author":[{"given":"Jun\u2010Ping","family":"Liu","sequence":"first","affiliation":[{"name":"School of Medicine Institute of Ageing Research Hangzhou Normal University Hangzhou Zhejiang Province China"},{"name":"Department of 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