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The effects of electrical lesions in the basolateral amygdala nucleus (\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    ) were investigated on the locomotor activity and anxiety\u2010like behaviour in different stress durations. For this purpose, rats were randomly allocated to control, sham, and experimental groups, the latter including groups with and without\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    nucleus subjected to acute, sub\u2010chronic, and chronic stress conditions for 1, 7, and 21\u00a0days, respectively, applied 6\u00a0h\/d. The induced anxiety behaviour was evaluated using the open field test (\n                    <jats:styled-content style=\"fixed-case\">OFT<\/jats:styled-content>\n                    ) while other variables were measured. Findings revealed that sub\u2010chronic stress led to significantly reduced (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05) anxiety behaviours as measured by entries into and the time spent in the centre area while it also led to significant impairments in exploratory and locomotor activities, indicating intensified anxiety\u2010like behaviour.\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    lesion affected rat behaviour differently such that it significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05) decreased fear under sub\u2010chronic and chronic stress conditions as evidenced by the subjects\u2019 greater tendency to enter the centre area in the open field test and their increased number of rearing events (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.01). However,\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    lesion led to no significant decrease in the locomotor activity of subjects exposed to sub\u2010chronic or chronic stress conditions as compared with those in similar groups but without\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    lesion. Finally,\n                    <jats:styled-content style=\"fixed-case\">BLA<\/jats:styled-content>\n                    lesion was found not only to decrease significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.01) adrenal gland and body weights, particularly under sub\u2010chronic stress, but also to play a critical role in modulating adrenal functions by decreasing adrenal gland weight, and thereby reducing depression\u2010like symptoms.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.12727","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T02:18:57Z","timestamp":1483755537000},"page":"470-479","source":"Crossref","is-referenced-by-count":32,"title":["Effects of electrical lesion of basolateral amygdala nucleus on rat anxiety\u2010like behaviour under acute, sub\u2010chronic, and chronic 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