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The serotonin system is implicated in cholestatic itch; however, the pruritogenic properties of serotonin have not been evaluated in cholestatic mice. Here, we investigated the serotonin\u2010induced itch in cholestatic mice which was induced by bile duct ligation (<jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content>). Serotonin, sertraline or saline were administered intradermally to the rostral back area in <jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content> and sham operated (<jats:styled-content style=\"fixed-case\">SHAM<\/jats:styled-content>) mice, and the scratching behaviour was videotaped for 1\u00a0hour. Bile duct ligated mice had significantly increased scratching responses to saline injection on the seventh day after surgery. Additionally, serotonin or sertraline significantly induced scratching behaviour in <jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content> mice compared to saline at day 7 after surgery, while it did not induce itch at day 5. The scratching behaviour induced by serotonin or sertraline was significantly less in <jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content> mice compared to <jats:styled-content style=\"fixed-case\">SHAM<\/jats:styled-content> mice. Likewise, the locomotor activity of <jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SHAM<\/jats:styled-content> mice was not significantly different from unoperated (<jats:styled-content style=\"fixed-case\">UNOP<\/jats:styled-content>) mice on the fifth and seventh day, suggesting that the scratching behaviour was not affected by motor dysfunctions. Our data suggest that despite the potentiation of evoked itch, a resistance to serotonin\u2010induced itch is developed in cholestatic mice.<\/jats:p>","DOI":"10.1111\/1440-1681.12752","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T05:59:42Z","timestamp":1489903182000},"page":"680-685","source":"Crossref","is-referenced-by-count":8,"title":["Development of resistance to serotonin\u2010induced itch in bile duct ligated mice"],"prefix":"10.1111","volume":"44","author":[{"given":"Sattar","family":"Ostadhadi","sequence":"first","affiliation":[{"name":"Brain and Spinal Cord Injury Research Center Neurosciences Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Experimental Medicine Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences  Tehran 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