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The activation of the canonical cAMP<\/jats:styled-content>\/PKA<\/jats:styled-content> pathway depends on transmembrane adenylyl cyclase (tmAC<\/jats:styled-content>). Recently, soluble adenylyl cyclase (sAC<\/jats:styled-content>), which is activated by HCO<\/jats:styled-content>3<\/jats:sub>\u2212<\/jats:sup> or Ca2+<\/jats:sup>, emerges to provide an alternative way to activate cAMP<\/jats:styled-content>\/PKA<\/jats:styled-content> pathway with the cystic fibrosis transmembrane conductance regulator (CFTR<\/jats:styled-content>), a cAMP<\/jats:styled-content>\u2010activated Cl\u2212<\/jats:sup>\/HCO<\/jats:styled-content>3<\/jats:sub>\u2212<\/jats:sup>\u2010conducting anion channel, as a key player. This review summarizes new progress in the investigation of the CFTR<\/jats:styled-content>\/HCO<\/jats:styled-content>3<\/jats:sub>\u2212<\/jats:sup>\u2010dependent sAC<\/jats:styled-content> signalling and its essential role in various reproductive processes, particularly in ovarian functions. We present the evidence for a CFTR<\/jats:styled-content>\/HCO<\/jats:styled-content>3<\/jats:sub>\u2212<\/jats:sup>\u2010dependent nuclear sAC<\/jats:styled-content> signalling cascade that amplifies the FSH<\/jats:styled-content>\u2010stimulated cAMP<\/jats:styled-content>\/PKA<\/jats:styled-content> pathway, traditionally thought to involve tmAC<\/jats:styled-content>, in granulosa for the regulation of oestrogen production and granulosa cell proliferation. The implication of the CFTR<\/jats:styled-content>\/HCO<\/jats:styled-content>3<\/jats:sub>\u2212<\/jats:sup>\/sAC<\/jats:styled-content> pathway in amplifying other receptor\u2010activated cAMP<\/jats:styled-content>\/PKA<\/jats:styled-content> signalling in a wide variety of cell types and pathophysiological processes, including aging, is also discussed.<\/jats:p>","DOI":"10.1111\/1440-1681.12756","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T07:53:19Z","timestamp":1490601199000},"page":"78-85","source":"Crossref","is-referenced-by-count":12,"title":["Amplification of FSH<\/scp> signalling by CFTR<\/scp> and nuclear soluble adenylyl cyclase in the ovary"],"prefix":"10.1111","volume":"44","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Epithelial Cell Biology Research Center School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Sha Tin NT Hong Kong SAR 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