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Recent studies have demonstrated that\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    is pathogenic in a number of diseases including hypertensive cardiovascular and kidney complications, diabetic nephropathy, and acute and chronic kidney diseases. It is well known that\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    binds its receptor,\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    32\/\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    64, to induce the process of inflammation by activating the\n                    <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\n                    \u2010\u03baB signalling pathway. In addition,\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    mediates tissue fibrosis in a number of cardiovascular and kidney diseases by activating\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b2\/Smad signalling via\n                    <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\n                    \u2010\u03b21\u2010dependent and independent mechanisms. Furthermore,\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    is able to activate\n                    <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>\n                    signalling in the diabetic conditions. Our recent studies also revealed that\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    impairs cell regeneration by causing the G1 cell cycle arrest and promotes ageing via a Smad3\u2010dependent p21\/p27 mechanism. In this review, we discuss the roles of\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    in ageing, with a focus on its function and mechanisms in physiological or \u201chealthy\u201d ageing, in ageing\u2010related diseases, and in cell signalling.\n                  <\/jats:p>","DOI":"10.1111\/1440-1681.12758","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:27:09Z","timestamp":1491398829000},"page":"9-14","source":"Crossref","is-referenced-by-count":130,"title":["C\u2010reactive protein and ageing"],"prefix":"10.1111","volume":"44","author":[{"given":"Ying","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Nephrology Sun Yat\u2010Sen Memorial Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Medicine and 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