{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:02:43Z","timestamp":1768449763154,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Pharma Physio"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The aim of this study was to evaluate cardiovascular autonomic modulation in response to an orthostatic stress in healthy subjects and Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>). The study included 47 controls and 56 <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients divided into groups (vasoconstrictor <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, vasodilator <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, control) according to vasodilation\/vasoconstriction response during 70\u00b0 head up tilt test. Using impedance cardiography (<jats:styled-content style=\"fixed-case\">ICG<\/jats:styled-content>) and electrocardiography (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>) we measured stroke volume, cardiac output, left ventricular work index, left ventricular ejection time, acceleration index, index of contractility, Heather index, thoracic fluid content, total peripheral resistance, total arterial compliance. We also analyzed heart rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>), using spectral analysis and continuous blood pressure (contBP). At rest, the vasodilator <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group showed significantly higher values of total peripheral resistance and lower values of stroke volume and cardiac output, compared to the vasoconstrictor <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and the control groups. A post\u2010tilt drop in \u2206 (change rest \u2013 tilt) systolic blood pressure, \u2206mean blood pressure, \u2206total peripheral resistance and \u2206Heather index, and a significantly lower increase in \u2206diastolic blood pressure was observed in subjects from the vasodilator <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group compared to the vasoconstrictor <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and the control groups. No statistically significant differences were observed for <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> parameters between the vasoconstrictor and vasodilator <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> groups, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05. Longer duration and higher disease stage of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> correlated with a reduction in post\u2010tilt systolic blood pressure changes in vasodilator group. Positive inotropy of the cardiac muscle represents a significant factor preventing orthostatic hypotension in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> subjects with a concurrent drop in peripheral vascular resistance during orthostatic stress.<\/jats:p>","DOI":"10.1111\/1440-1681.12809","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T04:58:42Z","timestamp":1499317122000},"page":"1089-1098","source":"Crossref","is-referenced-by-count":5,"title":["Role of peripheral vascular resistance as an indicator of cardiovascular abnormalities in patients with Parkinson's disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-7113","authenticated-orcid":false,"given":"Monika","family":"Zawadka\u2010Kunikowska","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomy Faculty of Health Sciences Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"S\u0142omko","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomy Faculty of Health Sciences Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Tafil\u2010Klawe","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Faculty of Medicine Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum in Bydgoszcz  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek J","family":"Klawe","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomy Faculty of Health Sciences Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun  Bydgoszcz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Cudnoch\u2010J\u0119drzejewska","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology Laboratory of Centre for Preclinical Research Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia L","family":"Newton","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine The Medical School, Newcastle University  Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Zalewski","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomy Faculty of Health Sciences Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun  Bydgoszcz 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