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We aimed to investigate the anti\u2010influenza role of curcumin in vitro and in vivo. The effect of curcumin on replication of influenza A virus (<jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>) was examined in human lung cancer cell line A549, as well as in a mouse model. Curcumin could inhibit <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content> in vitro and alleviate the severity of the disease in the mouse after infection with <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>. The results also indicated that curcumin could trigger expression of Heme oxygenase\u20101 in vivo and attenuate <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content>\u2010induced injury to the lung tissue. Furthermore, curcumin could regulate immune response following <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content> infection through inhibiting production of local inflammatory cytokines. In addition, curcumin was found to inhibit <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB signalling in macrophages, as well as the subsequent production of cytokines\/chemokines responding to <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content> infection, by enhancing I\u03baB\u03b1 and <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>. Our current study supports the potential of curcumin as a promising treatment against <jats:styled-content style=\"fixed-case\">IAV<\/jats:styled-content> infection, whose effect may be mediated by regulating immune response to prevent injury to the lung tissue.<\/jats:p>","DOI":"10.1111\/1440-1681.12848","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T22:59:25Z","timestamp":1504047565000},"page":"84-93","source":"Crossref","is-referenced-by-count":84,"title":["Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production"],"prefix":"10.1111","volume":"45","author":[{"given":"Shuguang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of Respiratory Medicine Nanjing Medical University Affiliated Wuxi Second Hospital  Wuxi 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