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The possible toxic synergism with aspirin and acetaminophen, however, is not previously described; though case reports suggest such co\u2010toxicities with low levels of aspirin and other compounds can exist. In vitro studies into mechanistic processes of salicylate toxicity propose that there is a bi\u2010directional link and potentiation with glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>) depletion and salicylate toxicity. Data may suggest a plausible explanation for salicylate and acetaminophen toxic synergism. Further studies investigating this potential toxic synergism are warranted. Given the lack of awareness in the clinical community about potential toxic synergism between these relatively common medications, caution is advised in the co\u2010administration of these drugs, particularly in communities using natural or alternative therapy.<\/jats:p>","DOI":"10.1111\/1440-1681.12861","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T16:31:46Z","timestamp":1506357106000},"page":"117-121","source":"Crossref","is-referenced-by-count":17,"title":["Co\u2010ingestion of aspirin and acetaminophen promoting fulminant liver failure: A critical review of Reye syndrome in the current perspective at the dawn of the 21st century"],"prefix":"10.1111","volume":"45","author":[{"given":"Deepak","family":"Dinakaran","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Alberta  Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-7879","authenticated-orcid":false,"given":"Consolato M","family":"Sergi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathology University of Alberta  Edmonton AB Canada"},{"name":"Wuhan University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1465"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90554-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91362-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJM199909093411112","article-title":"Reye's syndrome","volume":"341","author":"Hall SM","year":"1999","journal-title":"N Engl J Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200709030-00008"},{"key":"e_1_2_6_7_1","first-page":"54","article-title":"Emergency: Reye syndrome","volume":"103","author":"Kamienski MC","year":"2003","journal-title":"Am J Nurs"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2008.06.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13262"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.18433\/J36G6X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.5.351"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259913"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130230012004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.10.959"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(12)80114-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810397047"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92553-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91947-1"},{"key":"e_1_2_6_19_1","first-page":"115","article-title":"The mechanism of inhibition of beta\u2010oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome patients and controls","volume":"31","author":"Glasgow JF","year":"1999","journal-title":"Biochem Biophys Acta"},{"key":"e_1_2_6_20_1","first-page":"243","article-title":"Autophagy\u2010inflammasome interplay in heart failure: a systematic review on basics, pathways, and therapeutic perspectives","volume":"47","author":"Chiu B","year":"2017","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.12.1499"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000083296.57581.AE"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036325"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.121"},{"key":"e_1_2_6_25_1","first-page":"1097","article-title":"Investigation of an epidemic of Reye's syndrome in northern region of India","volume":"36","author":"Ghosh D","year":"1999","journal-title":"Indian Pediatr"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91481-O"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23475"},{"key":"e_1_2_6_28_1","unstructured":"CourtsD.How to Make Aspirin from Willow Tree. 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